Results 1 to 10 of about 205,571 (213)

Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma

Biomedicines, 2022
Inhaled corticosteroids (ICS) remain the mainstay of asthma treatment, along with bronchodilators serving as control agents in combination with ICS or reliever therapy.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Elena Pistocchini, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Molecular mimicry of HIV gp120: Possible implications on prevention and therapy of AIDS [PDF]

Archive of Oncology, 2005
A broad range of similarities between HIV-1 gp120 and human proteins-especially those participating in immune responses-highlight gp120 as a pleiotropic protein which can influence many important functions of the human immune system.
Veljković Nevena V.
doaj   +1 more source

Immunogenicity and Safety of Investigational MenABCWY Vaccine and of 4CMenB and MenACWY Vaccines Administered Concomitantly or Alone: a Phase 2 Randomized Study of Adolescents and Young Adults

mSphere, 2021
This phase 2, randomized, open-label study assessed the immunogenicity and safety of an investigational meningococcal ABCWY vaccine (MenABCWY) that contains components of licensed vaccines against meningococcal serogroup B (4CMenB) and serogroups ACWY ...
Jiří Beran, Daniel Dražan, Igwebuike Enweonye, Chiranjiwi Bhusal, Daniela Toneatto   +4 more
doaj   +1 more source

Strategic Improvement of Oral Antineoplastic Investigational Agents Compliance [PDF]

Global Journal on Quality and Safety in Healthcare, 2019
Background: The use of oral antineoplastic agents has increased in cancer medicine. However, the convenience of oral medication carries the risk of nonadherence and dosing errors, which could jeopardize therapeutic benefits and patient safety.
Anas Alshawa, Jing Gong, Valerie Marcott, Rabia Khan, Valentine Boving, Lakeshia Brown, Jeff Beno, Ed Kheder, Siqing Fu   +8 more
doaj   +1 more source

Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects

Pharmacology Research & Perspectives, 2021
This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated.
Xiaoshu Dai, Michael D. Karol, Matthew Hitron, Marjie L. Hard, John Evan Blanchard, Nicola C. J. E. Eraut, Natalie Rich, Brandon T. Gufford   +7 more
doaj   +1 more source

Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors

Cancer Medicine, 2022
Background Arginine depletion interferes with pyrimidine metabolism and DNA damage repair pathways. Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI‐PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in
Shuyang Yao, Filip Janku, Kimberly Koenig, Apostolia Maria Tsimberidou, Sarina Anne Piha‐Paul, Nai Shi, John Stewart, Amanda Johnston, John Bomalaski, Funda Meric‐Bernstam, Siqing Fu   +10 more
doaj   +1 more source

Hurdles and signposts on the road to virtual control groups—A case study illustrating the influence of anesthesia protocols on electrolyte levels in rats

Frontiers in Pharmacology, 2023
Introduction: Virtual Control Groups (VCGs) represent the concept of using historical control data from legacy animal studies to replace concurrent control group (CCG) animals.
A. Gurjanov, A. Kreuchwig, T. Steger-Hartmann, L. A. I. Vaas   +3 more
doaj   +1 more source

Selinexor in combination with standard chemotherapy in patients with advanced or metastatic solid tumors

Experimental Hematology & Oncology, 2021
Selinexor, an oral selective inhibitor of nuclear export (SINE), was demonstrated to hinder the DNA damage repair (DDR) system by reducing DDR proteins while enhancing the killing of cancer cells by DDR-based therapeutics in vivo studies.
Kyaw Z. Thein, Sarina A. Piha-Paul, Apostolia Tsimberidou, Daniel D. Karp, Filip Janku, Siqing Fu, Vivek Subbiah, David S. Hong, Timothy A. Yap, Jatin Shah, Denái R. Milton, Lacey McQuinn, Jing Gong, Yanyan Tran, Brett W. Carter, Rivka Colen, Funda Meric-Bernstam, Aung Naing   +17 more
doaj   +1 more source

Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences

Scientific Reports, 2022
Cyclin E is frequently encoded by CCNE1 gene amplification in various malignancies. We reviewed the medical records of patients with solid tumors displaying CCNE1 amplification to determine the effect of this amplification for future therapeutic ...
Shuyang Yao, Funda Meric-Bernstam, David Hong, Filip Janku, Aung Naing, Sarina Anne Piha-Paul, Apostolia Maria Tsimberidou, Daniel Karp, Vivek Subbiah, Timothy Anthony Yap, Jordi Rodon Ahnert, Shubham Pant, Ecaterina E Ileana Dumbrava, Chetna Wathoo, Erick Campbell, Lihou Yu, Yuko Yamamura, Siqing Fu   +17 more
doaj   +1 more source

Nontraumatic Dental Condition-related Visits to Emergency Departments on Weekdays, Weekends and Night Hours: Findings from the National Hospital Ambulatory Medical Care Survey [PDF]

, 2013
Objective: To determine whether the rates of nontraumatic dental condition (NTDC)-related emergency department (ED) visits are higher during the typical working hours of dental offices and lower during night hours, as well as the associated factors ...
Fischer, Melissa Christine, Okunseri, Christopher, Okunseri, Elaye, Sadeghi, Saba Noori, Szabo, Aniko, Xiang, Qun   +5 more
core   +2 more sources