Results 11 to 20 of about 205,670 (312)
Pembrolizumab in Patients with Advanced Miscellaneous Rare Cancers: Results from a Phase 2 Basket Trial [PDF]
Journal of Immunotherapy and Precision OncologyIntroduction Rare solid tumors account for one-quarter of cancers among adults in the United States, but few resources have been devoted to their treatment. We evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with
Mirella Nardo +7 more
doaj +1 more source
Good clinical practice in clinical interventional studies [PDF]
, 2014 Good clinical practice (GCP) guidelines should always be implemented and obeyed in clinical interventional studies. In this mini-review, we will address several burning questions relating to GCP in a concise ‘frequently asked questions’ format.While ...
Diamant, Zuzana, Pieterse, Herman
core +3 more sources
Scientific Reports, 2022 Patients with rare solid tumors treated on early phase trials experience toxicities from their tumors and treatments. However, limited data exist to describe the detailed symptom burden suffered by these patients, particularly those with rare solid ...
Tito R. Mendoza +22 more
doaj +1 more source
Providing Hope: Developing a Viable Regulatory Framework for Providing Terminally Ill Patients With Adequate Access to Investigational Drugs [PDF]
, 2008 “If I die . . . I want my children to know I did everything I could.” This is a common feeling among terminally ill individuals facing death. This desire to exhaust every option often causes people to fight to receive potentially toxic and dangerous ...
Sikora, James P.
core +2 more sources
Experimental Hematology & Oncology, 2020 Background Angiogenesis and activation of the epidermal growth factor (EGFR) pathway play an essential role in tumor proliferation and metastasis. Targeting angiogenesis or EGFR alone does not yield adequate tumor control in most solid tumors. Overcoming
Vivek Subbiah +12 more
doaj +1 more source
Patient Characteristics and Trends in Nontraumatic Dental Condition Visits to Emergency Departments in the United States [PDF]
, 2012 Objective: We examined trends and patient characteristics for non-traumatic dental condition (NTDC) visits to emergency departments (EDs), and compared them to other ED visit types, specifically non-dental ambulatory care sensitive conditions (non-dental
Okunseri, Christopher +4 more
core +2 more sources
Ustekinumab for the treatment of psoriatic arthritis: an update. [PDF]
, 2014 Psoriatic arthritis occurs in 30% of psoriasis patients, and the treatment can be challenging in some patients. Recently, the US Food and Drug Administration approved ustekinumab, a fully human monoclonal antibody, for the management of psoriatic ...
Davari, Parastoo +3 more
core +1 more source
npj Precision Oncology, 2022 We investigated the challenges of conducting IMPACT2, an ongoing randomized study that evaluates molecular testing and targeted therapy (ClinicalTrials.gov: NCT02152254).
Henry Hiep Vo +22 more
doaj +1 more source
Criteria for the use of omics-based predictors in clinical trials. [PDF]
, 2013 The US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to 'omics'-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based
A Dupuy +25 more
core +2 more sources
Evaluation of Novel Oral Vaccine Candidates and Validation of a Caprine Model of Johne's Disease
Frontiers in Cellular and Infection Microbiology, 2014 Johne’s disease (JD) caused by Mycobacterium avium subspecies paratuberculosis (MAP) is a major threat to the dairy industry and possibly some cases of Crohn’s disease in humans.
Murray E. Hines +12 more
doaj +1 more source