Patient-Reported Outcome Measures after Multilevel Lumbar Total Disc Arthroplasty for the Treatment of Multilevel Degenerative Disc Disease [PDF]
, 2020 STUDY DESIGN: Case series OBJECTIVE.: The aim of this study was to assess the patient reported outcome measures (PROMs) and patient satisfaction of multi-level lumbar total disc arthroplasty (TDA) for symptomatic multilevel degenerative disc disease ...
Furness, James +6 more
core +1 more source
Scientific Reports, 2023 Several alterations in fibroblast growth factor receptor (FGFR) genes have been found in breast cancer; however, they have not been well characterized as therapeutic targets.
Turcin Saridogan +15 more
doaj +1 more source
The Ethics of Placebo-controlled Trials: Methodological Justifications [PDF]
, 2013 The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven ...
Grady, Christine, Millum, Joseph
core +1 more source
An analysis of common ethical justifications for compassionate use programs for experimental drugs [PDF]
, 2016 BACKGROUND: When a new intervention or drug is developed, this has to pass through various phases of clinical testing before it achieves market approval, which can take many years.
Raus, Kasper
core +1 more source
npj Precision Oncology, 2023 Combined BRAF + MEK inhibition is FDA approved for BRAF V600E-mutant solid tumors except for colorectal cancer. However, beyond MAPK mediated resistance several other mechanisms of resistance such as activation of CRAF, ARAF, MET, P13K/AKT/mTOR pathway ...
Blessie Elizabeth Nelson +15 more
doaj +1 more source
A first-in-human, randomized, controlled, subject- and reviewer-blinded multicenter study of Actamax™ Adhesion Barrier [PDF]
, 2016 Purpose: Post-surgical adhesions remain a significant concern following abdominopelvic surgery. This study was to assess safety, manageability and explore preliminary efficacy of applying a degradable hydrogel adhesion barrier to areas of surgical ...
Brucker, Sara Y. +12 more
core +2 more sources
Associations between the gut microbiome and fatigue in cancer patients
Scientific Reports, 2021 Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients.
Joud Hajjar +14 more
doaj +1 more source
Which Design and Biomaterial Factors Affect Clinical Wear Performance of Total Disc Replacements? A Systematic Review [PDF]
, 2014 Background Total disc replacement was clinically introduced to reduce pain and preserve segmental motion of the lumbar and cervical spine. Previous case studies have reported on the wear and adverse local tissue reactions around artificial prostheses ...
Alexander, Dominik D. +4 more
core +2 more sources
Response to “Radiation Therapeutic Gain and Asian Botanicals,” by Stephen Sagar [PDF]
, 2010 Numerous botanical agents, many of which are used in whole medical system practices (i.e. traditional Chinese medicine, Ayurvedic medicine, etc.), have been shown to exhibit radiomodifying effects on tumors and normal tissues in-vitro and invivo studies.
Lawenda, Brian D.
core +1 more source
Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults [PDF]
, 2016 Background: Non-typeable Haemophilus influenzae (NTHi) is a major cause of various respiratory diseases. The development of an effective vaccine against NTHi mandates new approaches beyond conjugated vaccines as this opportunistic bacterium is non ...
Aris, Emmanuel +7 more
core +2 more sources