Results 121 to 130 of about 206,973 (317)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Theory of investigative action by S. A. Shafer (on the occasion of the Teacher’s anniversary)

open access: yesЮридический вестник Самарского университета
The issue of the concept of investigative action, which has been in the center of attention of Russian processualists for many decades, has been studied «inside and out» by both masters of Russian science and many of their followers, and to this day ...
V. A. Lazareva
doaj   +1 more source

Behind Enemy Phone Lines: Insider Trading, Parallel Enforcement, and Sharing the Fruits of Wiretaps [PDF]

open access: yes, 2015
Two key trends were present in the successful prosecution of Raj Rajaratnam and his coconspirators in one of the largest insider-trading conspiracies in history: the use of wiretaps to investigate and prosecute insider trading and a joint effort between ...
Mogul, Alexandra N.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Participation of Specialists in a Criminal Proceeding Involving the Investigation of Criminal Offenses Related to Domestic Violence

open access: yesАрхів кримінології та судових наук
Specific expertise which procedural form is engagement of a specialist in investigative (search) actions is crucial in solving the majority of tactical tasks. Given that the indicated issue in the context of criminal offenses related to domestic violence
Anhelina Salnikova
doaj   +1 more source

Semi-Annual Report to Congress for the Period of April 1, 2014 to September 30, 2014 [PDF]

open access: yes, 2014
[Excerpt] I am pleased to submit this Semiannual Report to the Department and the Congress, which highlights the most significant activities and accomplishments of the U.S.
Office of the Inspector General
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy