Results 51 to 60 of about 2,113,797 (268)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Partners, coordinators and high-level leaders’ perspectives on a consumer and community involvement program in Australia: a qualitative evaluation using template analysis

BMC Health Services Research
A Consumer and Community Involvement program located in Australia supports consumers, community members and researchers to work in partnership with health research priorities, policy and practice.
James Smith, Howard Lance, Susan Hayes
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

To involve or not to involve?

, 2023
Het zorgsysteem staat onder druk. Dit heeft alles te maken met de stijgende complexe zorgvraag en schaarste in zorgpersoneel. Dit heeft ertoe geleid dat de druk op bedden in het ziekenhuis enorm is, waardoor patiënten sneller en daardoor vaak ook zieker dan voorheen naar huis gaan.
openaire   +1 more source

Engaging adults with severe mental illness in research: considerations and practical recommendations for meaningful patient and public involvement

Research Involvement and Engagement
Background Patient and public involvement (PPI) in mental health research is essential but presents unique challenges, particularly when engaging adults with severe mental illness (SMI).
Emily Shoesmith, Petal Petersen Williams, Jennifer Sweetman, Lisa Huddlestone, Jodi Pervin, Simon Hough, Susan Croft, Steven Dexter, Coleen Scothorne, Elena Ratschen   +9 more
doaj   +1 more source

WOMEN INVOLVEMENT IN CASSAVA VALUE CHAIN AMONG CASSAVA PROCESSORS AND MARKETERS IN AFIJIO LOCAL GOVERNMENT AREA, OYO STATE, NIGERIA

Russian Journal of Agricultural and Socio-Economic Sciences, 2021
There have been several governmental approaches and interventions to increase the production of cassava crop in Nigeria which have not been yielding desired results due to market linkage failure.
Azeez F.A., Usman J.M., Obadimu O.O., Mukarumbwa P., Kabir G.B.   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Filologia e Lingüística: enlace, divórcio, reconciliação

Filologia e Linguística Portuguesa, 1998
The article deals with the relationships between Philology and Linguistics along the history of the studies of the language and seeks to define the respective objects and fields of analysis. It presents the question of the philology’s ambiguity, pointing
Pierre Swiggers, Lineide do Lago Salvador Mosca (traduction)   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source