Results 61 to 70 of about 2,113,797 (268)

Liver Involvement [PDF]

Deutsches Ärzteblatt international, 2020
Alexander L, Gerbes, Sabine, Weber
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

“We’re all in this together”: patient and public involvement and engagement in developing a new psychosocial intervention for adults with an intellectual disability who display aggressive challenging behaviour

Research Involvement and Engagement
Background Although there is consensus regarding the added value of adults with an intellectual disability and family carers as Patient and Public Involvement and Engagement (PPIE) members in research studies, there is limited reporting on the practice ...
Connor Clarke, Athanasia Kouroupa, Rachel Royston, Angela Hassiotis, Yufei Jin, Vivien Cooper, Robert Daniels, Lisa Grimley, Sue Hay, Louise Marston, Olawole Odeyemi, Ian Penfold, Claire Pullar, Penny Rapaport, Kate Sanger, Adam Southworth, Laurence Taggart, Afia Ali   +17 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Integration of patient and public involvement in a doctoral research study using the research cycle

Research Involvement and Engagement
Background Patient and public involvement (PPI) in research is widely acknowledged as essential to achieving successful and impactful research. Despite this acknowledgement, there are limited reports on how to approach and apply meaningful PPI throughout
Helen Pearson, Carol Bell, Karl Cox, Catherine Kayum, Leona Knox, Faith Gibson, Michelle Myall, Anne-Sophie Darlington, Emma Potter, Nicholas Bird   +9 more
doaj   +1 more source

Evaluation of the Establishment of a Public and Patient Involvement and Engagement Group to Support Clinical Trials in Pakistan: Protocol for a Mixed-Methods Study [version 2; peer review: 2 approved]

Wellcome Open Research
Background Patient and public involvement and engagement (PPIE) in research is a collaboration between researchers, patients, and the public, enhancing research acceptability, relevance, and impact.
Monaza Khan, Shehla Farooq, Srinivas Murthy, Nikhat Ahmed, Saima Saleem, Adnan Masood, Shahnaz Zaman, Zahyd Shuja, Arishay Hussaini, Timo Tolppa, Arjen M Dondorp, Madiha Hashmi   +11 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ocular involvement of brucellosis

Middle East African Journal of Ophthalmology, 2013
A 29-year-old male diagnosed with brucellosis a week earlier was referred to the ophthalmology clinic with visual complaints. On examination, visual acuity was 20/25, he had conjunctival injection on slit lamp examination. There was also bilateral optic disk swelling plus retinal hyperemia (optic disc hyperemia and vascular tortuosity) and intraretinal
Bazzazi, Nooshin, Yavarikia, Alireza, Keramat, Fariba   +2 more
openaire   +3 more sources

Feasibility of early digital health rehabilitation after cardiac surgery in the elderly: a qualitative study

BMC Health Services Research
Background Increasing numbers of elderly patients experience prolonged decreased functional capacity and impaired quality of life after seemingly successful cardiac surgery.
Bente Skovsby Toft, Lotte Ørneborg Rodkjær, Lotte Sørensen, Marianne Rørbæk Saugbjerg, Hilary Louise Bekker, Ivy Susanne Modrau   +5 more
doaj   +1 more source