Results 51 to 60 of about 25,018 (225)

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Institutional Barriers to Continuous Professional Development (CPD) Programs

Journal of University Medical & Dental College
BACKGROUND AND OBJECTIVE: Continuous Professional Development (CPD) Programs aim to support the career progression of faculty members by leveraging their professional experiences, theoretical knowledge, research, and professionalism with colleagues ...
Maaz Ahmad, Laraib Qamar, H.M. Owais Nasim, Rab Nawaz Lodhi, Usman Ashraf, Saeed Shafi   +5 more
doaj   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Rhinoceros Serum microRNAs: Identification, Characterization, and Evaluation of Potential Iron Overload Biomarkers

Frontiers in Veterinary Science, 2021
Iron overload disorder (IOD) in critically endangered Sumatran (Dicerorhinus sumatrensis) and black (Diceros bicornis) rhinoceros is an over-accumulation of iron in organs which may exacerbate other diseases and indicate metabolic disturbances.
Jessye Wojtusik, Erin Curry, Terri L. Roth   +2 more
doaj   +1 more source

Durch einen stabilisierten Intermediatkomplex vermittelte Friedel‐Crafts‐Alkylierung auf Oberflächen

Angewandte Chemie, EarlyView.
Einblicke in eine Csp3${\rm C}_{sp^{3}}$‐Csp2${\rm C}_{sp^{2}}$‐Kupplung an Edelmetalloberflächen werden anhand einer oberflächenvermittelten Friedel‐Crafts‐Alkylierung auf Ag(111) gegeben. STM, XPS und DFT‐Rechnungen klären den Reaktionsmechanismus auf Einzelmolekülebene und die Stabilisierung des zentralen Intermediats auf.
Paul Schweer, Christoph J. Vonnemann, Nishanth Arumugam, Stefan M. Huber, Daniel P. Miller, Karina Morgenstern   +5 more
wiley   +1 more source

Beiträge zur Chemie polyvalenter Iod-Verbindungen [PDF]

, 2000
Die vorliegende Dissertation befaßt sich mit der Darstellung und Charakterisierung von polyvalenten Iod-Verbindungen. Der erste Teil beschreibt trifluormethyl-substituierte Iod(III)-Moleküle des Typs CF3IX2 (X = F, Cl, OCH3, OCOCF3) und CF3I(Cl)Y (Y = F,
Berkei, Michael
core   +1 more source

JOINT DISTRIBUTION AND PROBABILITY DENSITY OF CLIMATE FACTORS IN KALIMANTAN USING NESTED COPULAS

Barekeng
In this study, we investigate the joint distribution of local and global climate factors in Kalimantan, Indonesia, using fully and partially nested copula models. The analysis focuses on capturing the dependencies between local factors (precipitation and
Sri Nurdiati, Teduh W. Mas’oed, Mohamad K. Najib, Dewi Rahmawati   +3 more
doaj   +1 more source

THE EFFECT OF THE INDIAN OCEAN DIPOLE PHENOMENON AND THE CATCHING OF LONG-JAWED MACKEREL (RASTRELIGGER SPP) IN LAMPUNG WATERS [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
The Indian Ocean Dipole (IOD) is a symptom of climate aberrations caused by the interaction of the ocean and the atmosphere in the Indian Ocean. IOD can influence oceanographic parameters and the density of chlorophyll-a in the waters, affecting fish ...
Pamungkas S., Parmanto
doaj