Results 61 to 70 of about 27,323 (272)

Stereokontrollierte Synthese von fluorierten Isochromanen durch Iod(I)/Iod(III)‐Katalyse

Angewandte Chemie, 2022
AbstractDer Erfolg von gesättigten, fluorierten Heterozyklen im Anwendungsbereich der modernen Arzneimittel bietet einen Anreiz für die Weiterentwicklung der Hauptgruppenelement‐Katalyse. Motiviert durch die Alleinstellung von Isochromanen im Spektrum der bioaktiven kleinen Molekülen, wurden entsprechende fluorierte Analoga stereoselektiv mithilfe von ...
Joel Häfliger, Olga O. Sokolova, Madina Lenz, Constantin G. Daniliuc, Ryan Gilmour   +4 more
openaire   +1 more source

Selbstassemblierte (Aza‐)BODIPY Farbstoffe für Biomedizinische In Vivo Bildgebung

Angewandte Chemie, EarlyView.
Dieses Minireview klassifiziert (Aza‐)BODIPY‐Farbstoffe anhand ihrer molekularen Stapelungsmodi und Aggregattypen (H‐, oblique‐ oder J‐Typ) in wässrigen Medien und setzt diese Merkmale in Beziehung zu ihrer multimodalen Bildgebungsleistung. Durch die Verknüpfung von molekularem Design, Exzitonenkopplung und pfadabhängiger Assemblierung stellen wir ...
Antonia Albers, Max Masthoff, Gustavo Fernández   +2 more
wiley   +1 more source

Extreme IOD induced tropical Indian Ocean warming in 2020

Geoscience Letters, 2021
The tropical Indian Ocean (TIO) basin-wide warming occurred in 2020, following an extreme positive Indian Ocean Dipole (IOD) event instead of an El Niño event, which is the first record since the 1960s.
Ying Zhang, Yan Du
semanticscholar   +1 more source

Insulinlike growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

THE EFFECT OF THE INDIAN OCEAN DIPOLE PHENOMENON AND THE CATCHING OF LONG-JAWED MACKEREL (RASTRELIGGER SPP) IN LAMPUNG WATERS [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
The Indian Ocean Dipole (IOD) is a symptom of climate aberrations caused by the interaction of the ocean and the atmosphere in the Indian Ocean. IOD can influence oceanographic parameters and the density of chlorophyll-a in the waters, affecting fish ...
Pamungkas S., Parmanto
doaj  

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

JOINT DISTRIBUTION AND PROBABILITY DENSITY OF CLIMATE FACTORS IN KALIMANTAN USING NESTED COPULAS

Barekeng
In this study, we investigate the joint distribution of local and global climate factors in Kalimantan, Indonesia, using fully and partially nested copula models. The analysis focuses on capturing the dependencies between local factors (precipitation and
Sri Nurdiati, Teduh W. Mas’oed, Mohamad K. Najib, Dewi Rahmawati   +3 more
doaj   +1 more source

Tropical Volcanic Eruptions and Low Frequency Indo‐Pacific Variability Drive Extreme Indian Ocean Dipole Events

Geophysical Research Letters, 2023
Volcanic eruptions can have significant climate impacts and serve as useful natural experiments for better understanding the effects of abrupt, externally forced climate change. Here, we investigate the Indian Ocean Dipole's (IOD) response to the largest
Benjamin H. Tiger, Caroline C. Ummenhofer   +1 more
doaj   +1 more source

The IOD–ENSO Interaction: The Role of the Indian Ocean Current’s System

Atmosphere, 2021
The Indian Ocean dipole (IOD) is one of the main modes characterizing the interannual variability of the large-scale ocean–atmosphere interaction in the equatorial zone of the World Ocean.
A. Polonsky, A.V. Torbinsky
semanticscholar   +1 more source