Results 61 to 70 of about 516,124 (306)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Bisphenol A increases hydrogen peroxide generation by thyrocytes both in vivo and in vitro

Endocrine Connections, 2018
Bisphenol A (BPA) is the most common monomer in polycarbonate plastics and an endocrine disruptor. Though some effects of BPA on thyroid hormone (TH) synthesis and action have been described, the impact of this compound on thyroid H2O2 generation remains
Maurício Martins da Silva, Lueni Lopes Felix Xavier, Carlos Frederico Lima Gonçalves, Ana Paula Santos-Silva, Francisca Diana Paiva-Melo, Mariana Lopes de Freitas, Rodrigo Soares Fortunato, Leandro Miranda-Alves, Andrea Claudia Freitas Ferreira   +8 more
doaj   +1 more source

Iodine Biofortification of Apples and Pears in an Orchard Using Foliar Sprays of Different Composition

Frontiers in Plant Science, 2021
Many people across the world suffer from iodine (I) deficiency and related diseases. The I content in plant-based foods is particularly low, but can be enhanced by agronomic biofortification.
Christoph Budke, Werner Dierend, Hans-Georg Schön, Katja Hora, Karl Hermann Mühling, Diemo Daum   +5 more
doaj   +1 more source

Simple method of making photovoltaic junctions Patent [PDF]

, 1967
Gallium arsenide solar cell preparation by surface deposition of cuprous iodide on thin n-type polycrystalline layers and heating in iodine ...
Ellis, S. G.
core   +1 more source

New Insights into the Charge-Transfer-to-Solvent Spectrum of Aqueous Iodide: Surface versus Bulk. [PDF]

, 2020
Liquid phase charge-transfer-to-solvent (CTTS) transitions are important, as they serve as photochemical routes to solvated electrons. In this work, broadband deep-ultraviolet electronic sum frequency generation (DUV-ESFG) and two-photon absorption (2PA)
Bhattacharyya, Dhritiman, Bradforth, Stephen E, Mizuno, Hikaru, Rizzuto, Anthony M, Saykally, Richard J, Zhang, Yuyuan   +5 more
core  

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]

, 2016
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad, Ahn, Carlson, Carrasco, Carrasco, Carrasco, Carrasco, Carrasco, Clarke, Desai, Dirbas, Dominguez, Gambhir, Gonzalez-Angulo, Grollman, Harrington, Haveman, Ikeda, Jhiang, Jhiang, Jhiang, Kalkanis, Kang, Kirova, Lawrence, Lawrence, Lind, Link, Liu, Lorusso, Mier, Morris, Neuwelt, Nishimura, Russell, Schlumberger, Seidman, Smith, Spitzweg, Steeg, Studebaker, Vermorken, Vermorken, Wapnir, Wapnir, Wapnir, Wapnir   +46 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of the salt 2-iodoethylammonium iodide – a possible side product upon synthesis of hybrid perovskites

Acta Crystallographica Section E: Crystallographic Communications
The title organic–inorganic hybrid salt, C2H7IN+·I−, is isotypic with its bromine analog, C2H7BrN+·Br− [Semenikhin et al. (2024). Acta Cryst. E80, 738–741]. Its asymmetric unit consists of one 2-iodoethylammonium cation and one iodide anion.
Hanna R. Petrosova, Dina D. Naumova, Irina A. Golenya, Ildiko Buta, Il'ya A. Gural'skiy   +4 more
doaj   +1 more source

High Sensitivity Mass Spectrometric Quantification of Serum Growth Hormone by Amphiphilic Peptide Conjugation [PDF]

, 2012
Amphiphilic peptide conjugation affords a significant increase in sensitivity with protein quantification by electrospray-ionization mass spectrometry.
Arsene, Arsene, Barkan, Busch, Cech, Cech, Chai, Chanson, Foettinger, Frahm, Giustina, Halquist, Hofmann, Kulevich, Ligon, Litterscheid, Markkanen, Mirzaei, Shortreed, Shuford, Ullmer, Williams, Williams, Wu, Yang, Yang   +25 more
core   +1 more source