Results 231 to 240 of about 114,579 (263)

Site-Specific PEGylation at Residue 86 Improves Pharmacokinetic Properties of Interferon α-2b. [PDF]

Iran J Biotechnol
Alboshokeh MA, Mirshekar S, Hedayati MH, Gholami A, Javdani Shahedin G, Arabi Mianroodi R.   +5 more
europepmc   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

The Effects of Counter-Ions on Peptide Structure, Activity, and Applications. [PDF]

Biomolecules
Liu Y, Huang Y, Yang L, Gao Y, Jia Z, Liu T, Su B, Wang C, Jin L, Zhang D.   +9 more
europepmc   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Investigation of the antimycobacterial potential and toxicity evaluation of a proteinaceous compound from Streptomyces qinglanensis VITABS23 against Mycobacterium tuberculosis strains. [PDF]

Trop Med Health
Babu AS, Rao KVB.
europepmc   +1 more source

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide‐induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2

Animal Models and Experimental Medicine, EarlyView.
The interaction between mitofusin 2 (MFN2) and phosphofurin acidic cluster sorting protein 2 regulates the formation of mitochondria‐associated endoplasmic reticulum membranes (MAM). Overexpression of MFN2 can promote the formation of MAMs and inhibit inflammation and oxidative stress response in mammary epithelial cells.
Xiechen Zhou, Yufei Zhang, He Ma, Shoupeng Fu, Juxiong Liu, Wenjin Guo, Xiaofeng Tian, Bingxu Huang   +7 more
wiley   +1 more source

Regio- and stereoselective <i>tert</i>-butylthiolation of internal alkynes with thioethers initiated and maintained by silylium-ion catalysis. [PDF]

Chem Sci
Morgan DM, Klare HFT, Oestreich M.
europepmc   +1 more source

Protocol - Recombinant expression of human COX2 in insect cells using the Bac-to-Bac system and purification by ion exchange and size-exclusion chromatography

Antonio Vico-Padilla, Diana Moreno García, David López-Martínez, JUAN ANTONIO GIMENEZ BASTIDA   +3 more
openalex   +1 more source

Toward Translation of Cowpea Mosaic Virus Intratumoral Immunotherapy With a Scalable Production Process. [PDF]

Plant Biotechnol J
Opdensteinen P, Affonso de Oliveira JF, Jung S, Steinmetz NF.   +3 more
europepmc   +1 more source

Beta Toxins Isolated from the Scorpion <i>Centruroides hirsutipalpus</i> (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals. [PDF]

Toxins (Basel)
Valdez-Velazquez LL, Olamendi-Portugal T, Restano-Cassulini R, Riaño-Umbarila L, Jiménez-Vargas JM, Zamudio F, Salazar-Monge H, Becerril B, Possani LD.   +8 more
europepmc   +1 more source