Results 31 to 40 of about 91,721 (252)

Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles

Frontiers in Pharmacology, 2018
Bile acids have received considerable interest in the drug delivery research due to their peculiar physicochemical properties and biocompatibility.
Nebojša Pavlović, Svetlana Goločorbin-Kon, Maja Ðanić, Bojan Stanimirov, Hani Al-Salami, Karmen Stankov, Momir Mikov   +6 more
doaj   +1 more source

Cold quantum gases: coherent quantum phenomena from Bose-Einstein condensation to BCS pairing of fermions [PDF]

, 2004
Studies of trapped quantum gases of bosons and of fermions have opened up a new range of many-body problems, having a strong overlap with nuclear and neutron star physics.
Abo-Shaeer, Abuki, Alpar, Anderson, Andrews, Arnold, Arnold, Arnold, Bartenstein, Baym, Baym, Baym, Baym, Baym, Baym, Baym, Baym, Bloch, Bourdel, Bradley, Bretin, Brown, Bruun, Carlson, Chen, Chin, Coddington, Coddington, Cooper, Cornish, Cubizolles, Davis, DeMarco, Diener, Eagles, Engels, Fischer, Gasser, Gehm, Gelman, Gordon Baym, Greiner, Grüter, Haljan, Hebel, Heiselberg, Ho, Holland, Holzmann, Holzmann, Itakura, Jackson, Jackson, Jochim, Kaplan, Kasamatsu, Kashurnikov, Kavoulakis, Kavoulakis, Kinast, Kinast, Krawczyk, Kundu, Leggett, Leggett, Lundh, Migdal, Milstein, Nozières, O'Hara, Pandharipande, Regal, Regal, Regnault, Reijnders, Schweikhard, Schäfer, Strecker, Stringari, Viefers, Watanabe, Wilkin, Wilkin, Zwierlein, Zwierlein   +84 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Guanidinium Like‐Charge Ion Pairing and Oligoarginine Aggregation in Water by Nuclear Magnetic Resonance, Cryo‐Electron Microscopy, and Molecular Dynamics

Aggregate
Like‐charge pairing is a physical manifestation of the unique solvation properties of certain ion pairs in water. Water's high dielectric constant and related charge screening capability significantly influence the interaction between like‐charged ions ...
Denys Biriukov, Zuzana Osifová, Man Thi Hong Nguyen, Philip E. Mason, Martin Dračínský, Pavel Jungwirth, Jan Heyda, Mattia I. Morandi, Mario Vazdar   +8 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

What limits supercurrents in high temperature superconductors? A microscopic model of cuprate grain boundaries

, 2009
The interface properties of high-temperature cuprate superconductors have been of interest for many years, and play an essential role in Josephson junctions, superconducting cables, and microwave electronics.
A Gurevich, B. M. Andersen, BM Andersen, BM Andersen, C-R Hu, D Dimos, FC Zhang, G Hammerl, H Hilgenkamp, ID Brown, J. Mannhart, JC Slater, JK Freericks, M Sigrist, M Sigrist, O Chmaissem, P Chaudhari, P Liu, P. J. Hirschfeld, R. Gutser, RC Baetzold, S Lee, S. Graser, SJ Pennycook, SR Phillpot, SV Stolbov, T Löfwander, T Yokoyama, T. Kopp, WA Harrison, X Zhang, Y Tanaka, Y Tanaka, Y Tanaka, YuS Barash   +34 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Electron pairing: from metastable electron pair to bipolaron

, 2018
Starting from the shell structure in atoms and the significant correlation within electron pairs, we distinguish the exchange-correlation effects between two electrons of opposite spins occupying the same orbital from the average correlation among many ...
Brito, Braulio G. A., Cândido, Ladir, Hai, Guo-Qiang, Peeters, François M.   +3 more
core   +1 more source

Competition Between T=0 and T=1 Pairing in Proton-Rich Nuclei [PDF]

, 1996
A cranked mean-field model with two-body T=1 and T=0 pairing interactions is presented. Approximate projection onto good particle-number is enforced via an extended Lipkin-Nogami scheme.
Aboussir, Anantaraman, Chen, Engel, Goodman, Goodman, Goodman, Goodman, Goswami, Goswami, Myers, Möller, Müller, Nichols, Pradhan, R. Wyss, Rosenfeld, W. Satuła, Wigner, Wolter   +19 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source