Results 331 to 340 of about 4,602,690 (366)
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Current Opinion in Pediatrics, 2001
Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
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Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
openaire +2 more sources
2010
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and ...
ARCANGELI, A, BECCHETTI A
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Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and ...
ARCANGELI, A, BECCHETTI A
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Phosphorylation of Ion channels
The Journal of Membrane Biology, 1985The introduction of highly specific reagents such as enzymes and inhibitors directly into living cells has proven to be a powerful tool in studying the modulation of cellular activity by protein phosphorylation. The use of exogenous kinases can be thought of as a pharmacological approach: this demonstrates that phosphorylation can produce modulation ...
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Science, 1997
A brief touch can trigger immediate flight in an animal. In his Perspective, Grillner discusses a finding reported on page 1122 of this issue by Viana di Prisco et al . that may underlie this response. Transient stimulation on the skin of a lamprey causes a long-lasting excitation of the neurons that control motor behaviors, initiating ...
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A brief touch can trigger immediate flight in an animal. In his Perspective, Grillner discusses a finding reported on page 1122 of this issue by Viana di Prisco et al . that may underlie this response. Transient stimulation on the skin of a lamprey causes a long-lasting excitation of the neurons that control motor behaviors, initiating ...
openaire +3 more sources
Biochemical Society Transactions, 2007
Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation to neurotransmitter release.
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Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation to neurotransmitter release.
openaire +3 more sources
Advances in TRP channel drug discovery: from target validation to clinical studies
Nature Reviews Drug Discovery, 2022Ari-pekka Koivisto +2 more
exaly
Natural courtship song variation caused by an intronic retroelement in an ion channel gene
Nature, 2016Yun Ding +4 more
semanticscholar +1 more source
Regulating excitability of peripheral afferents: emerging ion channel targets
Nature Neuroscience, 2014S. Waxman, G. Zamponi
semanticscholar +1 more source