Results 31 to 40 of about 325,795 (314)
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
eLife, 2023 CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings.
Márton A Simon +3 more
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Ion channel activity drives ion channel expression [PDF]
The Journal of Physiology, 1998 During embryonic development, excitable cells acquire a repertoire of ion channels that finely tune their electrical properties. Although the mechanisms by which an excitable cell selects its complement of ion channels are poorly defined, cell-autonomous as well as non-autonomous programmes of differentiation have been implicated.
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Circulation: Arrhythmia and Electrophysiology, 2009 The analysis of the molecular basis of the inherited cardiac arrhythmias has been the driving force behind the identification of the ion channels that generate the action potential. The genes encoding all the major ion channels have cloned and sequenced. The studies have revealed greater complexity than heretofore imagined.
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eLife, 2016 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov +3 more
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Pharmaceutical Biology, 2020 Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang +8 more
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Frontiers in Physiology, 2022 Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet +12 more
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Channels, 2015 Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time, off-target interactions of drugs with cardiac ion channels can be the cause of unwanted side ...
Birgit T, Priest, Jeff S, McDermott
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eLife, 2019 Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov +3 more
doaj +1 more source
Biomolecules, 2020 Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo +3 more
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Frontiers in Molecular Biosciences, 2021 Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifying ...
Mariela González-Avendaño +21 more
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