Results 31 to 40 of about 948,699 (249)
Scientific Reports, 2019 The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse +4 more
doaj +1 more source
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
eLife, 2023 CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings.
Márton A Simon +3 more
doaj +1 more source
Self-consistent analytic solution for the current and the access resistance in open ion channels. [PDF]
, 2009 A self-consistent analytic approach is introduced for the estimation of the access resistance and the current through an open ion channel for an arbitrary number of species.
Kaufman, I. +3 more
core +1 more source
The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation
Journal of Advanced Research, 2021 Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Mei Liu, Qinghuan Xiao
doaj +1 more source
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]
, 2014 Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro +5 more
core +1 more source
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
Nature Communications, 2016 The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh +12 more
doaj +1 more source
Activity-dependent regulation of T-type calcium channels by submembrane calcium ions
eLife, 2017 Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade +3 more
doaj +1 more source
Multiple Thresholds in a Model System of Noisy Ion Channels [PDF]
, 2006 Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model.
D. Johnston +5 more
core +1 more source
Frontiers in Physiology, 2022 Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet +12 more
doaj +1 more source