Results 31 to 40 of about 1,025,431 (370)

Ion Channels of Nociception [PDF]

International Journal of Molecular Sciences, 2020
The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes, nociceptive roles of P2X3, ASIC, Piezo and TRP ...
openaire   +3 more sources

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

Antibiotics, 2023
One of the global challenges of the 21st century is the increase in mortality from infectious diseases against the backdrop of the spread of antibiotic-resistant pathogenic microorganisms.
Olga S. Ostroumova, Svetlana S. Efimova
doaj   +1 more source

PH regulation of amphotericin B channels activity in the bilayer lipid membrane [PDF]

, 2016
Background: Amphotericin B (AmB) is a polyene antibiotic frequently applied in the treatment of systemic fungal infections in spite of its secondary effects.
Ashrafpour, M., Sepehry, H., Shahmoradi, T.   +2 more
core   +2 more sources

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

eLife, 2019
Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov, Balázs Tóth, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na_V1.5 Mutant of the Long QT Type 3 Syndrome

Biomolecules, 2020
Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo, Alejandro López-Requena, Julio L. Alvarez, Karel Talavera   +3 more
doaj   +1 more source

PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data

Frontiers in Molecular Biosciences, 2021
Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifying ...
Mariela González-Avendaño, Mariela González-Avendaño, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Ian Silva, Ian Silva, Boris Lavanderos, Boris Lavanderos, Felipe Robinson, Felipe Robinson, Roberto Rosales-Rojas, Roberto Rosales-Rojas, Fabio Durán-Verdugo, Wendy González, Wendy González, Mónica Cáceres, Mónica Cáceres, Oscar Cerda, Oscar Cerda, Ariela Vergara-Jaque, Ariela Vergara-Jaque   +21 more
doaj   +1 more source

Charge fluctuations and boundary conditions of biological ion channels:effect on the ionic transition rate [PDF]

, 2009
A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge
Eisenberg, R. S., Luchinsky, D. G., McClintock, P. V. E., Tindjong, R.   +3 more
core   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

The ion-channel laser [PDF]

, 1990
A relativistic electron beam propagating through a plasma in the ion-focused regime exhibits an electromagnetic instability at a resonant frequency {omega} {approximately} 2{gamma}{sup 2} {omega}{sub {beta}}. Growth is enhanced by optical guiding in the ion channel, which acts as dielectric waveguide, with fiber parameter V {approximately} 2 (I/I{sub A}
Whittum, D H, Sessler, A M, Dawson, J M
openaire   +5 more sources