Results 81 to 90 of about 2,488,331 (299)

The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

Frontiers in Pharmacology, 2011
Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several
Francesco eMiceli, MariaVirginia eSoldovieri, Fabio Arturo Iannotti, Vincenzo eBarrese, Paolo eAmbrosino, Maria eMartire, Maria Roberta Cilio, Maurizio eTaglialatela, Maurizio eTaglialatela   +8 more
doaj   +1 more source

Recombinant glycine receptors: stoichiometry and kinetics [PDF]

, 2009
Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
core  

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

Coupling ligand binding to ion channel gating in NMDA receptors [PDF]

, 2011
The NMDA receptor is a ligand-gated ion channel that mediates a fundamental component of excitatory synaptic transmission in the mammalian central nervous system.
Talukder, Iehab
core   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Direct electrical access to presynaptic ion channels has hitherto been limited to large specialized terminals such as the calyx of Held or hippocampal mossy fiber bouton.
Rusakov, Dmitri A., Korchev, Yuri E., Moss, Guy WJ, Ermolyuk, Yaroslav S, Volynski, Kirill E, Bailey, Russell J, Bailey, Russell J., Moss, Guy W.J., Klenerman, David, Volynski, Kirill E., Rusakov, Dmitri A, Novak, Pavel, Shevchuk, Andrew I, Bushby, Andrew J, Vivekananda, Umesh, Kullmann, Dimitri M., Kullmann, Dimitri M, Shevchuk, Andrew I., Gorelik, Julia, Korchev, Yuri E, Ermolyuk, Yaroslav S., Bushby, Andrew J., Benton, DCH, Caldwell, M, Moss, GWJ, Smart, TG, Robertson, AD   +26 more
core   +1 more source

Bio‐Inspired Artificial Ionic Mechanoreceptor

Advanced Functional Materials, EarlyView.
A skin‐inspired artificial mechanoreceptor based on ionic interactions is presented for biomimetic tactile sensing. Pressure‐driven ionic redistribution within microfluidic channels generates a self‐powered electrical signal without external bias. The generated waveform exhibits mechanoreceptor‐like temporal features, including overshoot and undershoot,
Mohammad Akbari, Jeppe Don, Lasse A. N. Pedersen, John Noee, Rassoul Tabassian   +4 more
wiley   +1 more source

Lipid-mediated hydrophobic gating in the BK potassium channel

Nature Communications
Structures of the large-conductance, calcium-activated potassium (BK) channel in the Ca2+ −bound and Ca2+ −free states have suggested that K+ conduction is not gated via a steric closure of the pore-lining helices of the channel, in contrast to the ...
Lucia Coronel, Giovanni Di Muccio, Brad S. Rothberg, Alberto Giacomello, Vincenzo Carnevale   +4 more
doaj   +1 more source

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source

Structure-based membrane dome mechanism for Piezo mechanosensitivity

eLife, 2017
Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore,
Yusong R Guo, Roderick MacKinnon
doaj   +1 more source

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.

, 1995
Chloride channels of the ClC family are important for the control of membrane excitability, cell volume regulation, and possibly transepithelial transport.
Michael Pusch, Ludewig, U., Jentsch, T.J., Annett Rehfeldt, Rehfeldt, A., Thomas J. Jentsch, Uwe Ludewig, Jentsch, T. J., Pusch, M., Ludewig, Uwe   +9 more
core   +1 more source