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K+ Channels Gated by Voltage and Ions

Annual Review of Physiology, 1984
Several different potassium channels are present in membranes of nerve, muscle, and other types of cells (50, 59, 75, 79). These channels come in all sorts of sizes and shapes. K+ channels range from the tiny (2 pS) delayed rectifier of Helix neuron (72) to the huge Ca2+ -activated K+ channel (200 pS) ubiquitously distributed in many cells and tissues (
R, Latorre, R, Coronado, C, Vergara
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Are Ions Involved in the Gating of Calcium Channels?

Science, 1982
The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current ...
Y, Saimi, C, Kung
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The kinetics of voltage-gated ion channels

Quarterly Reviews of Biophysics, 1994
When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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Engineering Light-Gated Ion Channels

Biochemistry, 2006
Ion channels are gated by a variety of stimuli, including ligands, voltage, membrane tension, temperature, and even light. Natural gates can be altered and augmented using synthetic chemistry and molecular biology to develop channels with completely new functional properties.
Matthew R, Banghart   +2 more
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Molecular mechanisms of gated ion channels

Bioelectrochemistry and Bioenergetics, 1986
Abstract Ion channels form the basis for intercellular communication in biological systems. With the advent of cloning techniques, it is now possible to sequence the proteins that form such channels. The acetylcholine receptor, for example, which consists of five subunits, and the voltage gated sodium channel have been completely sequenced by Noda et
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The voltage sensor and the gate in ion channels

2003
Publisher Summary This chapter illustrates two aspects of ion channels: the gating process and the transduction from the initiating stimulus to the operation of the gate. The gating process is the operation of the gate proper while the transducer may be considered the sensor of the stimulus that ultimately opens and closes the channel.
Francisco, Bezanilla, Eduardo, Perozo
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Voltage Gated Ion Channels and Sleep

The Journal of Membrane Biology
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang   +5 more
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Ligand-gated ion channels

2012
Kenneth R. Tovar, Gary L. Westbrook
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Opening Ion Channels: Enzyme at the Gate

ChemMedChem, 2007
Jun, Chen, Murali, Gopalakrishnan
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Electrostatics of ligand-gated ion channels

Biochemical Society Transactions, 1998
C, Adcock, G R, Smith, M S, Sansom
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