Results 141 to 150 of about 5,224,105 (413)

Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons

Biomolecules
The endoplasmic reticulum (ER) is a key organelle in cellular homeostasis, regulating calcium levels and coordinating protein synthesis and folding. In neurons, the ER forms interconnected sheets and tubules that facilitate the propagation of calcium ...
Vyacheslav M. Shkryl
doaj   +1 more source

Analgesic Effects of Triterpenoid Saponins From Stauntonia chinensis via Selective Increase in Inhibitory Synaptic Response in Mouse Cortical Neurons

Frontiers in Pharmacology, 2018
Triterpenoid saponins from Stauntonia chinensis (TSS) are potential therapeutic agents because of its analgesic properties. However, the underlying mechanisms of the anti-nociceptive activity of TSS are largely unclear, especially in CNS.
Su Chen, Yi Rong, Mengxue Liu, Song Cheng, Xiangming Liu, Xiaohong Li, Yi Yu, Guangzhong Yang, Xiaofei Yang   +8 more
doaj   +1 more source

Correlation studies of open and closed states fluctuations in an ion channel: Analysis of ion current through a large conductance locust potassium channel [PDF]

, 2001
Ion current fluctuations occurring within open and closed states of large conductance locust potassium channel (BK channel) were investigated for the existence of correlation. Both time series, extracted from the ion current signal, were studied by the autocorrelation function (AFA) and the detrended fluctuation analysis (DFA) methods.
arxiv   +1 more source

Mechanosensitive ion channels

, 2016
Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell
Ken Takahashi, Yusuke Matsuda, K. Naruse
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

British Journal of Pharmacology, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org
Stephen P. H. Alexander, W. Catterall, E. Kelly, N. Marrion, J. A. Peters, H. E. Benson, E. Faccenda, Adam J Pawson, J. Sharman, C. Southan, J. Davies   +10 more
semanticscholar   +1 more source

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

A Python package for fast GPU‐based proton pencil beam dose calculation

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Open‐source GPU‐based Monte Carlo (MC) proton dose calculation algorithms provide high speed and unparalleled accuracy but can be complex to integrate with new applications and remain slower than GPU‐based pencil beam (PB) methods, which sacrifice some physical accuracy for sub‐second plan calculation.
Mahasweta Bhattacharya, Calin Reamy, Heng Li, Junghoon Lee, William T. Hrinivich   +4 more
wiley   +1 more source

Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis

Frontiers in Molecular Neuroscience, 2018
Complexins, binding to assembling soluble NSF-attachment protein receptor (SNARE) complexes, activate Ca2+ triggered exocytosis and clamp spontaneous release in the presynaptic terminal. Functions of complexin are structural dependent and mechanistically
Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang   +5 more
doaj   +1 more source

Voltage-Gated Ion Channels in Cancer Cell Proliferation

Cancers, 2015
Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions.
V. Rao, Mathew Perez-Neut, S. Kaja, S. Gentile   +3 more
semanticscholar   +1 more source

Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge, Reiner Geyer, Rémy Kinj, Luis Schiappacasse, Wendy Jeanneret‐Sozzi, Jean Bourhis, Fernanda Herrera, François Bochud, Claude Bailat, Raphaël Moeckli   +9 more
wiley   +1 more source