Results 71 to 80 of about 1,945,891 (284)

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Development of a unified gradient theory for ion-pair chromatography using oligonucleotide separations as a model case

, 2023
Ion-pair chromatography is the de facto standard for separating oligonucleotides and related impurities, particularly for analysis but also often for small-scale purification. Currently, there is limited understanding of the quantitative modeling of both
Fornstedt, Torgny, Samuelsson, Jörgen, Samuelsson, Jörgen,, Enmark, Martin,, Fornstedt, Torgny,, Enmark, Martin   +5 more
core   +1 more source

A new method for determination of fluoride ion in commodity tea by ion-exclusion chromatography

CyTA - Journal of Food, 2018
Due to the effect of interfering ion, the content of fluoride ion in tea brew, detected by ion-exchange chromatography, was markedly higher than ion-selective electrode.
Lili Zhou, Huaiping Li, Shanrong Ye, Heping Tan   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Silica based click amino stationary phase for ion chromatography and hydrophilic interaction liquid chromatography

, 2012
A silica based amino stationary phase was prepared by immobilization of propargylamine on azide-silica via click chemistry. This readily prepared click amino stationary phase demonstrated good selectivity in separation of common inorganic anions under ...
Du, Qing, Liu, Yajing, ChanghuChu, Liang, Xinmiao, 杨炳成, Chu, Changhu, Zhang, Feifang, Yang, Bingcheng   +7 more
core   +1 more source

Countercurrent chromatography in analytical chemistry (IUPAC technical report) [PDF]

, 2009
© 2009 IUPACCountercurrent chromatography (CCC) is a generic term covering all forms of liquid-liquid chromatography that use a support-free liquid stationary phase held in place by a simple centrifugal or complex centrifugal force field. Biphasic liquid
Sutherland, IA, Ian A. Sutherland, Tatyana Maryutina, Maryutina, T, Spivakov, B, Boris Spivakov, Shpigun, O, Berthod, A, Alain Berthod, Oleg Shpigun, Sutherland, Ian A., Iqbal, M. S., Torto, N., Lobinski, Ryszard, Labuda, J., Mester, Z., Motomizu, S., Trendafilova, N., Shpigun, Oleg, Smith, R. M., Knox, D. E., Lund, W., Fajgelj, A., Spivakov, Boris, Camoes, M., Maryutina, Tatyana, De Zorzi, P., Berthod, Alain, Hibbert, B., Chai, Z., Apak, R., Minkkinen, P., De Bieyre, P., Felinger, A., Aggarwal, S. K., Pingaron, J., Jarosz, M., Kim, H.   +37 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The derivation of bioprocess understanding from mechanistic models of chromatography [PDF]

, 2015
This thesis, completed in collaboration with Purification Process Development of Pfizer Biotherapeutics, is concerned with how mechanistic models of chromatographic bioseparations can be applied in industry to accelerate development and increase ...
Close, EJ
core  

Strategies for predictive modeling of overloaded oligonucleotide elution profiles in ion-pair chromatography

, 2023
Due to their potential for gene regulation, oligonucleotides have moved into focus as one of the preferred modalities modulating currently undruggable disease-associated targets.
Kaczmarski, Krzysztof, Fornstedt, Torgny, Samuelsson, Jörgen, Czechtizky, Werngard, Werngard Czechtizky, Jora, Manasses, Stavenhagen, Kathrin, Krzysztof Kaczmarski, Leek, Tomas, Marek Leśko, Manasses Jora, Kathrin Stavenhagen, Lesko, Marek, Torgny Fornstedt, Tomas Leek, Jörgen Samuelsson   +15 more
core   +1 more source