Results 51 to 60 of about 712,351 (297)
Separations, 2022 Product safety is important for medicines. For drugs on the market, it must be demonstrated that the levels of toxic contaminants are below the permitted limits. These impurities are used as reagents or are generated during synthesis.
Boglárka Páll +3 more
doaj +1 more source
Ion exchange chromatography – basic principles and application [PDF]
, 2011 Ion-Exchange Chromatography (IEC) allows for the separation of ionizable molecules on the basis of differences in charge properties. Its large sample-handling capacity, broad applicability (particularly to proteins and enzymes), moderate cost, powerful ...
Cummins, Phil +2 more
core
Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry [PDF]
, 2010 Background: Posaconazole is a novel antifungal drug for oral application intended especially for therapy of invasive mycoses. Due to variable gastrointestinal absorption, adverse side effects, and suspected drug-drug interactions, therapeutic drug ...
Burghardt, Stephan +4 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Clinical relevance of tissue copper, selenium, and cadmium alterations in colorectal cancer
Scientific ReportsImbalances in essential elements and altered levels of toxic elements are thought to play a role in colorectal cancer (CRC) development. This study assessed the concentrations of selected elements in CRC tissues and explored their associations with ...
Michał Kiełbus +10 more
doaj +1 more source
Moringa oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review
Frontiers in PharmacologyMoringa oleifera Lam. (Moringaceae) is a species of tree with an increasing utility, occurring naturally mainly in Pakistan and northern India. M. oleifera is currently cultivated in Africa, South America, Asia and the Middle East.
Marta Klimek-Szczykutowicz +8 more
doaj +1 more source
Antimicrobial activity of endophytic fungi Kabatiella caulivora Var. A from Alyxia reinwardtii Bl.
Journal of Biological Researches, 2012 Isolation and characterization of β-1,3-endoglucanase from cabbage (Brassica oleracea var. capitata L.) have been done. It showed 40° C of optimum temperature, and optimum pH is 7.
Y. Sri Wulan Manuhara
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Determination of Sulfate Ion in Ferric Oxide Powder by Ion Chromatography
Kuangchan zonghe liyongTo establish a method for the determination of sulfate ion in ferric oxide powder by ion chromatography with suppression conductivity detector. The hydrochloric acid was used to decomposed samples, with 1.0 mmol/L sodium bicarbonate and 3.2 mmol/L sodium
Yong LEI +5 more
doaj +1 more source
Development and application of an UHPLC-MS/MS method for the simultaneous determination of 17 steroidal hormones in equine serum [PDF]
, 2017 A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS ...
Allis +20 more
core +1 more source