Results 61 to 70 of about 397,097 (299)

Ion-exchange chromatography purification of extracellular vesicles

BioTechniques, 2017
Despite numerous studies, isolating pure preparations of extracellular vesicles (EVs) has proven challenging. Here, we compared ion-exchange chromatography (IEC) to the widely used sucrose density gradient (SDG) centrifugation method for the purification
Maja Kosanović, Bojana Milutinović, Sanja Goč, Ninoslav Mitić, Miroslava Janković   +4 more
doaj   +1 more source

Assessing glyphosate concentrations in six reservoirs of Paraíba do Sul and Guandu River Basins in southeast Brazil

Revista Ambiente & Água, 2021
Glyphosate is a popular herbicide used worldwide, and several studies consider it to be an environmental hazard affecting human health. The present study aimed to detect glyphosate in six different reservoirs of Paraíba do Sul and Guandu River Basins in ...
Carolina da Silva Cristofaro, Christina Wyss Castelo Branco, Maria Isabel de Almeida Rocha, Samira da Guia Mello Portugal   +3 more
doaj   +1 more source

Strategies for predictive modeling of overloaded oligonucleotide elution profiles in ion-pair chromatography

, 2023
Due to their potential for gene regulation, oligonucleotides have moved into focus as one of the preferred modalities modulating currently undruggable disease-associated targets.
Kaczmarski, Krzysztof, Fornstedt, Torgny, Samuelsson, Jörgen, Czechtizky, Werngard, Werngard Czechtizky, Jora, Manasses, Stavenhagen, Kathrin, Krzysztof Kaczmarski, Leek, Tomas, Marek Leśko, Manasses Jora, Kathrin Stavenhagen, Lesko, Marek, Torgny Fornstedt, Tomas Leek, Jörgen Samuelsson   +15 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Silica based click amino stationary phase for ion chromatography and hydrophilic interaction liquid chromatography

, 2012
A silica based amino stationary phase was prepared by immobilization of propargylamine on azide-silica via click chemistry. This readily prepared click amino stationary phase demonstrated good selectivity in separation of common inorganic anions under ...
Du, Qing, Liu, Yajing, ChanghuChu, Liang, Xinmiao, 杨炳成, Chu, Changhu, Zhang, Feifang, Yang, Bingcheng   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A new method for determination of fluoride ion in commodity tea by ion-exclusion chromatography

CyTA - Journal of Food, 2018
Due to the effect of interfering ion, the content of fluoride ion in tea brew, detected by ion-exchange chromatography, was markedly higher than ion-selective electrode.
Lili Zhou, Huaiping Li, Shanrong Ye, Heping Tan   +3 more
doaj   +1 more source

Development of an analytical method to detect cyanide in Chinese liquor by ion chromatography with pulsed amperometric detection

Zhongguo shipin weisheng zazhi, 2020
Objective This study aimed to develop an ion chromatography-pulse amperometry (IC-PAD) technique for the identification and quantification of cyanide in Chinese liquor. Methods The real samples from local markets were diluted to 1∶10 with ultrapure water
Zifei WANG, Hongjian MIAO, Pengjie LUO, Tiehu SUN, Xiaowei ZHENG, Jie GUO   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Split-ring resonator with interdigital Split electrodes as detector for liquid and ion chromatography

Sensing and Bio-Sensing Research
The analysis of food and drugs as well as the monitoring of chemical processes and bioreactors by high-performance liquid chromatography and ion chromatography requires universal, cost-effective, and sensitive detectors.
Kirsten J. Dehning, Moritz Hitzemann, Stefan Zimmermann   +2 more
doaj   +1 more source