Results 31 to 40 of about 566,568 (257)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Determination and Source Analysis of Hydrochemical Components in Different Water Bodies during the Normal Water Period in the Nandagang Wetland of Hebei Province, China

Yankuang ceshi
In recent years, the Nandagang wetland in Hebei Province has been facing a multidimensional water environmental crisis characterized by decreasing water volume, deteriorating water quality, and declining ecological service functions.
Jing RONG, Wenjing QU, Chaoyue WANG, Xiaogang FU, Fenggang DAI, Fanghong LI, Yahong ZHOU, Yaci LIU   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Increase of SARS-CoV-2 RNA load in faecal samples prompts for rethinking of SARS-CoV-2 biology and COVID-19 epidemiology [version 3; peer review: 2 approved]

F1000Research, 2021
Background Scientific evidence for the involvement of human microbiota in the development of COVID-19 disease has been reported recently. SARS-CoV-2 RNA presence in human faecal samples and SARS-CoV-2 activity in faeces from COVID-19 patients have been ...
Mauro Petrillo, Carlo Brogna, Simone Cristoni, Maddalena Querci, Ornella Piazza, Guy Van den Eede   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The efficiency of a focusing system when ion current transporting to the differential pumping system of a mass spectrometer

St. Petersburg Polytechnical University Journal: Physics and Mathematics
In this work, a charge particle beam transport in a corona discharge ion source with a thin diaphragm focusing system taking into account the gas-dynamic flow in the vicinity of the nozzle has been studied experimentally.
Pomozov Timofey, Muradymov Marat, Tkach Egor, Yavor Mikhail   +3 more
doaj   +1 more source

Modeling of plasma transport and negative ion extraction in a magnetized radio-frequency plasma source

New Journal of Physics, 2017
Negative ion sources for fusion are high densities plasma sources in large discharge volumes. There are many challenges in the modeling of these sources, due to numerical constraints associated with the high plasma density, to the coupling between plasma
G Fubiani, L Garrigues, G Hagelaar, N Kohen, J P Boeuf   +4 more
doaj   +1 more source

New Ion Source Filament for Prolonged Ion Source Operation on A Medical Cyclotron

Instruments, 2019
Cyclotrons are an important tool for accelerator sciences including the production of medical isotopes for imaging and therapy. For their successful and cost-efficient operation, the planned and unplanned down time of the cyclotron needs to be kept at a ...
Dave Prevost, Keerthi Jayamanna, Linda Graham, Sam Varah, Cornelia Hoehr   +4 more
doaj   +1 more source

Effects of ion extraction on discharges in gridded ion source

AIP Advances, 2022
Effects of ion extraction on gridded ion source discharge or the coupling between ion extraction and gridded ion source discharge are investigated for the first time by correlating the ratio of the ion impingement current (Ia) to ion beam current (Ib ...
Y. R. Yang, S. H. Fu, Z. F. Ding
doaj   +1 more source

Sources of Radioaciive Ions

IEEE Transactions on Nuclear Science, 1985
Beams of unstable nuclei can be formed by direct injection of the radioactive atoms into an ion source, or by using the momentum of the primary production beam as the basis for the secondary beam. The effectiveness of this latter mechanism in secondary beam formation, i.e.
openaire   +2 more sources