Results 51 to 60 of about 566,568 (257)

Cesiated surface H− ion source: optimization studies

New Journal of Physics, 2017
The H ^− ion beam intensity required for high-energy and high-intensity proton accelerators is continuously increasing. The required 95%-beam transverse normalized root mean square emittance ( ε _95%rnms _x _/ _y ) of the beam is around 0.25 π mm mrad ...
Akira Ueno
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Laser ion source for heavy ion inertial fusion

Matter and Radiation at Extremes, 2018
The proposed heavy ion inertial fusion (HIF) scenarios require ampere class low charge state ion beams of heavy species. The laser ion source (LIS) is recognized as one of the promising candidates of ion beam providers, since it can deliver high ...
Masahiro Okamura
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Achievement of high-current continuous-wave deuteron injector for linear IFMIF prototype accelerator (LIPAc)

Nuclear Fusion
The Linear IFMIF (International Fusion Materials Irradiation Facility) Prototype Accelerator (LIPAc) is aiming at demonstrating the low-energy section of a 40 MeV/125 mA IFMIF deuteron accelerator up to 9 MeV with a full beam current in continuous-wave ...
Tomoya Akagi, Benoît Bolzon, Yann Carin, Nicolas Chauvin, Fabio Cismondi, Hervé Dzitko, Kazuo Hasegawa, Tomonobu Itagaki, Atsushi Kasugai, Toshihiko Kitano, Keitaro Kondo, Kai Masuda, Masayoshi Sugimoto   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Elemental analysis of geological materials by a glow discharge mass spectrometry

Стандартные образцы, 2017
Advances of elemental analysis in geology are defined by the development and improvement ofphysical, instrumental methods of chemical analysis. New instrumental methods - emission spectrometry and mass spectrometry with inductively coupled plasma (ICP ...
A. I. Hanchuk, G. G. Siharulidze, K. S. Fokin, Y. A. Karpov   +3 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Research on Negative Helium Ion Beam Generation Technology

Yuanzineng kexue jishu
Tandem accelerator can generate MeV-level positive ion beam, of which He ion beam can be used for experimental research and industrial applications such as ion beam analysis and ion implantation, which is an indispensable ion beam for tandem accelerator.
CHEN Haonan1, 2, CUI Baoqun1, 2, TANG Bing1, 2, CHEN Lihua1, 2, MA Ruigang1, 2, MA Yingjun1, 2, MA Xie1, 2, ZHANG Yifan1, 2, ZHAO Jiange1, 2, WANG Yunfeng1, 2, YANG Chao1, 2, YU Rongkai1, 2
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source