Results 51 to 60 of about 594,915 (259)

Achievement of high-current continuous-wave deuteron injector for linear IFMIF prototype accelerator (LIPAc)

Nuclear Fusion
The Linear IFMIF (International Fusion Materials Irradiation Facility) Prototype Accelerator (LIPAc) is aiming at demonstrating the low-energy section of a 40 MeV/125 mA IFMIF deuteron accelerator up to 9 MeV with a full beam current in continuous-wave ...
Tomoya Akagi, Benoît Bolzon, Yann Carin, Nicolas Chauvin, Fabio Cismondi, Hervé Dzitko, Kazuo Hasegawa, Tomonobu Itagaki, Atsushi Kasugai, Toshihiko Kitano, Keitaro Kondo, Kai Masuda, Masayoshi Sugimoto   +12 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Elemental analysis of geological materials by a glow discharge mass spectrometry

Стандартные образцы, 2017
Advances of elemental analysis in geology are defined by the development and improvement ofphysical, instrumental methods of chemical analysis. New instrumental methods - emission spectrometry and mass spectrometry with inductively coupled plasma (ICP ...
A. I. Hanchuk, G. G. Siharulidze, K. S. Fokin, Y. A. Karpov   +3 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Research on Negative Helium Ion Beam Generation Technology

Yuanzineng kexue jishu
Tandem accelerator can generate MeV-level positive ion beam, of which He ion beam can be used for experimental research and industrial applications such as ion beam analysis and ion implantation, which is an indispensable ion beam for tandem accelerator.
CHEN Haonan1, 2, CUI Baoqun1, 2, TANG Bing1, 2, CHEN Lihua1, 2, MA Ruigang1, 2, MA Yingjun1, 2, MA Xie1, 2, ZHANG Yifan1, 2, ZHAO Jiange1, 2, WANG Yunfeng1, 2, YANG Chao1, 2, YU Rongkai1, 2
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tin–Lead Liquid Metal Alloy Source for Focused Ion Beams

Micromachines
Focused Ion Beam (FIB) systems are increasingly utilized in nanotechnology for nanostructuring, surface modification, doping, and rapid prototyping.
Bryan Flores, Shei Sia Su, Coleman Cariker, Ricardo A. Dacosta, Aaron M. Katzenmeyer, Alex A. Belianinov, Michael Titze   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Fault Detection Approach of Cyclotron Ion Sources Based on KPCA-ISSA-SVM

Sensors
To address the challenges of difficult feature extraction and suboptimal parameter configuration for cyclotron ion source fault diagnosis in complex environments, this study proposes an intelligent diagnostic framework integrating Kernel Principal ...
Yunlong Li, Yuntao Liu, Fengping Guan, He Zhang, Shigang Hou, Peng Huang, Zhujie Nong   +6 more
doaj   +1 more source