Results 61 to 70 of about 615,196 (306)

EISCAT/CRRES observations: Nightside ionospheric ion outflow and oxygen-rich substorm injections [PDF]

, 1996
We present combined observations made near midnight by the EISCAT radar, all-sky cameras and the combined released and radiation efects satellite (CRRES) shortly before and during a substorm.
Gazey, N. G. J., Aylward, A. D., Bunting, R., Wilken, B., Perry, C., Gazey, N.G.J., Bunting, R.J., Opgenoorth, H., Lockwood, M., Smith, P., Lockwood M, Coles S, Lockwood, Mike, Aylward AD, Aylward, A.D., Grandé, M., Coles, S., Gazey NGJ, Perry, C.H., Smith PN, Gazey, N., Smith, P. N., M. Grande, M. Gr, N. G. J. Gazey, Grande M, Bunting RJ, H. Opgenoorth, B. Wilken, A. D. Aylward, Smith, P.N., Bunting, R. J., Perry, C. H., Wilken B, M. Lockwood, S. Coles, Opgenoorth H, P. N. Smith, Perry CH, R. J. Bunting, Aylward, A., C. H. Perry   +41 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Advances in metal ion sources [PDF]

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1989
Abstract Beams of metallic ion species can be produced by the ECR (electron cyclotron resonance) ion source and by the MEVVA (metal vapor vacuum arc) ion source. Although the ECR source is fundamentally a gaseous ion source, metal ion beams can be produced by introducing metallic feed material into the plasma discharge using a number of techniques ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Characteristics of an ECR ion beam source for low-pressure etching

, 2022
S.2403-2405We have investigated an ECR ion beam source operated with a pair of coils and a two-grid extraction optics. The most important parameter for the source operation at low pressure (p smaller than 10 -3 mbar) is the magnetic field in the source ...
Scheer, H.-C., Neumann, G.
core   +1 more source

Cesiated surface H− ion source: optimization studies

New Journal of Physics, 2017
The H ^− ion beam intensity required for high-energy and high-intensity proton accelerators is continuously increasing. The required 95%-beam transverse normalized root mean square emittance ( ε _95%rnms _x _/ _y ) of the beam is around 0.25 π mm mrad ...
Akira Ueno
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Minipermanent magnet high-current microwave ion source

, 2006
A 2.45 GHz high-current microwave ion source with permanent magnet was developed at Peking University. The source body is about 10 cm in diameter and 10 cm in height, and its weight is less than 5 kg. It can operate in both pulse and continuous wave (cw)
Jianchuan Ming, Jinxiang Yu, Shixiang Peng, Zhizhong Song, Zhongxi Yuan, Feng Qian, Zhiyu Guo, Song, Zhizhong, Yu, Jinxiang, Qian, Feng, Ming, Jianchuan, Yuan, Zhongxi, Guo, Zhiyu, Peng, Shixiang   +13 more
core   +1 more source

Achievement of high-current continuous-wave deuteron injector for linear IFMIF prototype accelerator (LIPAc)

Nuclear Fusion
The Linear IFMIF (International Fusion Materials Irradiation Facility) Prototype Accelerator (LIPAc) is aiming at demonstrating the low-energy section of a 40 MeV/125 mA IFMIF deuteron accelerator up to 9 MeV with a full beam current in continuous-wave ...
Tomoya Akagi, Benoît Bolzon, Yann Carin, Nicolas Chauvin, Fabio Cismondi, Hervé Dzitko, Kazuo Hasegawa, Tomonobu Itagaki, Atsushi Kasugai, Toshihiko Kitano, Keitaro Kondo, Kai Masuda, Masayoshi Sugimoto   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source