Results 41 to 50 of about 615,196 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Yankuang ceshiIn recent years, the Nandagang wetland in Hebei Province has been facing a multidimensional water environmental crisis characterized by decreasing water volume, deteriorating water quality, and declining ecological service functions.
Jing RONG +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
F1000Research, 2021 Background Scientific evidence for the involvement of human microbiota in the development of COVID-19 disease has been reported recently. SARS-CoV-2 RNA presence in human faecal samples and SARS-CoV-2 activity in faeces from COVID-19 patients have been ...
Mauro Petrillo +5 more
doaj +1 more source
A Compact Microwave Ion Source [PDF]
IEEE Transactions on Nuclear Science, 1985 A small microwave ion source has been fabricated from a quartz tube with one end enclosed by a two grid accelerator. The source is also enclosed by a cavity operated at a frequency of 2.45 GHz. Microwave power as high as 500 W can be coupled to the source plasma. The source has been operated with and without multicusp fields for different gases. In the
Leung, K.N., Walther, S., Owren, H.W.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
St. Petersburg Polytechnical University Journal: Physics and MathematicsIn this work, a charge particle beam transport in a corona discharge ion source with a thin diaphragm focusing system taking into account the gas-dynamic flow in the vicinity of the nozzle has been studied experimentally.
Pomozov Timofey +3 more
doaj +1 more source
New Journal of Physics, 2017 Negative ion sources for fusion are high densities plasma sources in large discharge volumes. There are many challenges in the modeling of these sources, due to numerical constraints associated with the high plasma density, to the coupling between plasma
G Fubiani +4 more
doaj +1 more source
New Ion Source Filament for Prolonged Ion Source Operation on A Medical Cyclotron
Instruments, 2019 Cyclotrons are an important tool for accelerator sciences including the production of medical isotopes for imaging and therapy. For their successful and cost-efficient operation, the planned and unplanned down time of the cyclotron needs to be kept at a ...
Dave Prevost +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source