Results 71 to 80 of about 615,196 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Elemental analysis of geological materials by a glow discharge mass spectrometry
Стандартные образцы, 2017 Advances of elemental analysis in geology are defined by the development and improvement ofphysical, instrumental methods of chemical analysis. New instrumental methods - emission spectrometry and mass spectrometry with inductively coupled plasma (ICP ...
A. I. Hanchuk +3 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Development of Zeolite Ion Source for Beam Probe Measurements of High Temperature Plasma
, 2005 "A zeolite ion source has been developed for plasma diagnostics. Extracted beam current is increased by a factor of ~10 after redesigning the ion source structure and improving the method to make emitter material (zeolite).
Shimizu, A. +3 more
core
Research on Negative Helium Ion Beam Generation Technology
Yuanzineng kexue jishuTandem accelerator can generate MeV-level positive ion beam, of which He ion beam can be used for experimental research and industrial applications such as ion beam analysis and ion implantation, which is an indispensable ion beam for tandem accelerator.
CHEN Haonan1, 2, CUI Baoqun1, 2, TANG Bing1, 2, CHEN Lihua1, 2, MA Ruigang1, 2, MA Yingjun1, 2, MA Xie1, 2, ZHANG Yifan1, 2, ZHAO Jiange1, 2, WANG Yunfeng1, 2, YANG Chao1, 2, YU Rongkai1, 2
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Increase of Lifetime of Thallium Zeolite Ion Source for Single-Ended Accelerator
, 1995 "Utilizing multiple sintering, we have considerably increased the lifetime of a thallium (TI) zeolite ion source used in single-ended electrostatic accelerators.
"Nishizawa, A. +3 more
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Characterization of the FEBIAD Ion Source for the INFN-SPES Facility
, 2013 An intense research and development activity to finalize the design of the target ion source (TIS) system for the selective production of exotic species (SPES) facility (operating according to the isotope separation on line technique) is at present ...
ROSSIGNOLI, MASSIMO +9 more
core
Tin–Lead Liquid Metal Alloy Source for Focused Ion Beams
MicromachinesFocused Ion Beam (FIB) systems are increasingly utilized in nanotechnology for nanostructuring, surface modification, doping, and rapid prototyping.
Bryan Flores +6 more
doaj +1 more source