Results 41 to 50 of about 9,952,830 (307)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Determination and Source Analysis of Hydrochemical Components in Different Water Bodies during the Normal Water Period in the Nandagang Wetland of Hebei Province, China

Yankuang ceshi
In recent years, the Nandagang wetland in Hebei Province has been facing a multidimensional water environmental crisis characterized by decreasing water volume, deteriorating water quality, and declining ecological service functions.
Jing RONG, Wenjing QU, Chaoyue WANG, Xiaogang FU, Fenggang DAI, Fanghong LI, Yahong ZHOU, Yaci LIU   +7 more
doaj   +1 more source

New Ion Source Filament for Prolonged Ion Source Operation on A Medical Cyclotron

Instruments, 2019
Cyclotrons are an important tool for accelerator sciences including the production of medical isotopes for imaging and therapy. For their successful and cost-efficient operation, the planned and unplanned down time of the cyclotron needs to be kept at a ...
Dave Prevost, Keerthi Jayamanna, Linda Graham, Sam Varah, Cornelia Hoehr   +4 more
doaj   +1 more source

Rotational and nuclear-spin level dependent photodissociation dynamics of H2S

Nature Communications, 2021
The photodissociation dynamics of small molecules in the vacuum ultraviolet range can have key implications for astrochemical modelling, but revealing such dynamical details is a challenging task.
Yarui Zhao, Zijie Luo, Yao Chang, Yucheng Wu, Su-e Zhang, Zhenxing Li, Hongbin Ding, Guorong Wu, Jyoti S. Campbell, Christopher S. Hansen, Stuart W. Crane, Colin M. Western, Michael N. R. Ashfold, Kaijun Yuan, Xueming Yang   +14 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effects of ion extraction on discharges in gridded ion source

AIP Advances, 2022
Effects of ion extraction on gridded ion source discharge or the coupling between ion extraction and gridded ion source discharge are investigated for the first time by correlating the ratio of the ion impingement current (Ia) to ion beam current (Ib ...
Y. R. Yang, S. H. Fu, Z. F. Ding
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The efficiency of a focusing system when ion current transporting to the differential pumping system of a mass spectrometer

St. Petersburg Polytechnical University Journal: Physics and Mathematics
In this work, a charge particle beam transport in a corona discharge ion source with a thin diaphragm focusing system taking into account the gas-dynamic flow in the vicinity of the nozzle has been studied experimentally.
Pomozov Timofey, Muradymov Marat, Tkach Egor, Yavor Mikhail   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ion source of DMS-01 scientific equipment for «AIST no 2» small spacecraft

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
The main requirements imposed upon ion sources for on-board time-of-flight mass spectrometers are considered in the paper. An approximate formula to calculate the ionization cross section of an analyte substance is given.
N. D. Semkin, I. V. Piyakov, M. A. Rodina, D. V. Rodin   +3 more
doaj   +1 more source