Results 91 to 100 of about 850,090 (318)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prediction of plasma rotation velocity and ion temperature profiles in EAST Tokamak using artificial neural network models

Nuclear Fusion
Artificial neural network models have been developed to predict rotation velocity and ion temperature profiles on the EAST tokamak based on spectral measurements from the x-ray crystal spectrometer. Both Deep Neural Network (DNN) and Convolutional Neural
Zichao Lin, Hongming Zhang, Fudi Wang, Cheonho Bae, Jia Fu, Yongcai Shen, Shuyu Dai, Yifei Jin, Dian Lu, Shengyu Fu, Huajian Ji, Bo Lyu   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Lithium-ion Battery Module Temperature Monitoring by Using Planer Home-Made Micro Thermocouples

International Journal of Electrochemical Science, 2013
The battery management system is important to the safety of lithium-ion batteries. Safety is determined from the increase in temperature during operation. A traditional thermocouple is too large to insert in a lithium-ion battery module.
Shuo-Jen Lee, Chi-Yuan Lee, Ming-Yu Chung, Yi-Ho Chen, Kuo-Chang Han, Chao-Kai Liu, Wen-Chih Yu, Yu-Ming Chang   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ion stopping in dense plasma target for high energy density physics [PDF]

, 2010
The basic physics of nonrelativistic and electromagnetic ion stopping in hot and ionized plasma targets is thoroughly updated. Corresponding projectile-target interactions involve enhanced projectile ionization and coupling with target free electrons ...
Hasegawa, Jun, Sharkov, Boris Y., Deutsch, Claude, Chabot, Marin, Golubev, Alexey A., Ogawa, Masao, Bimbot, René, Jacoby, Joachim, Couillaud, Christophe, Mintsev, Victor, Della-Negra, Serge, Hoffmann, Dieter H. H., Wahl, H., Weyrich, Karin, Gardes, Daniel, Fleurier, Claude, Fertman, Alexander, Maynard, Gilles, Rivet, Marie-France, Tahir, Naeem Ahmad, Rosmej, Olga N., Fortov, Vladimir E., Oguri, Yoshiyuki   +22 more
core  

Threshold effects of tungsten impurity accumulation on core ion temperature in EAST tokamak

Nuclear Fusion
The critical threshold of the tungsten impurity concentration on the ion temperature in the core region is experimentally identified and studied in this paper. Sufficient experiments have demonstrated that the effect of tungsten impurity concentration on
H. Sheng, Y.W. Sun, L.Y. Chen, X. Jian, X.R. Zhang, Y.M. Duan, Y.Y. Li, J. Li, H.H. Wang, C. Ye, J.L. Chen, W.M. Zhang, S. Gu, M.N. Jia, Q. Ma, T.H. Shi, P.C. Xie, H. Yang, X.M. Wu, K.Y. He, X.M. Zhai, L. Zhang, H.L. Zhao, Y.H. Huan, J.F. Wang, G.H. Deng, J.Z. Shi, M.Y. Ye, B.N. Wan   +28 more
doaj   +1 more source

Diurnal variation of the ion temperature [PDF]

Journal of Atmospheric and Terrestrial Physics, 1969
Diurnal variations of ion temperature by Thomson scatter spectra in height range 250 to 475 ...
openaire   +1 more source