Results 11 to 20 of about 243,776 (300)

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

Cell Reports, 2019
Summary: mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1).
Wael L. Demian, Avinash Persaud, Chong Jiang, Étienne Coyaud, Shixuan Liu, Andras Kapus, Ran Kafri, Brian Raught, Daniela Rotin   +8 more
doaj   +3 more sources

The ion transporter superfamily

Biochimica Et Biophysica Acta - Biomembranes, 2003
We define a novel superfamily of secondary carriers specific for cationic and anionic compounds, which we have termed the ion transporter (IT) superfamily. Twelve recognized and functionally defined families constitute this superfamily. We provide statistical sequence analyses demonstrating that these families were in fact derived from a common ...
Prakash, Shraddha, Cooper, Garret, Singhi, Soumya, Saier, Milton H   +3 more
exaly   +3 more sources

Determinants of Ion-Transporter Cancer Cell Death. [PDF]

Chem, 2019
Park SH, Park SH, Howe ENW, Hyun JY, Chen LJ, Hwang I, Vargas-Zuñiga G, Busschaert N, Gale PA, Sessler JL, Shin I.   +10 more
europepmc   +2 more sources

Shen-Ling-Bai-Zhu-San (SL) and SL Derived-Polysaccharide (PL) Ameliorate the Severity of Diarrhea-Induced by High Lactose via Modification of Colonic Fermentation

Frontiers in Pharmacology, 2022
In our previous study, we demonstrated that Shen-ling-bai-zhu-san (SL), a classical Chinese herbal formula, could alleviate lactose-induced diarrhea. However, little is known about the mechanism underlying SL action or the efficacy of the polysaccharide (
Hong Xue, Jinxin Ma, Jinxin Ma, Yitian Wang, Mengxiong Lu, Mengxiong Lu, Fengyun Wang, Xudong Tang, Xudong Tang, Xudong Tang   +9 more
doaj   +1 more source

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]

, 2020
Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf, Kern, David M, Reid, Michelle S   +2 more
core   +2 more sources

Ferrous Ion Alleviates Lipid Deposition and Inflammatory Responses Caused by a High Cottonseed Meal Diet by Modulating Hepatic Iron Transport Homeostasis and Controlling Ferroptosis in Juvenile Ctenopharyngodon idellus

Antioxidants, 2023
To investigate the mechanisms through which ferrous ion (Fe2+) addition improves the utilization of a cottonseed meal (CSM) diet, two experimental diets with equal nitrogen and energy content (low-cottonseed meal (LCM) and high-cottonseed meal (HCM ...
Hengchen Liu, Shiyou Chen, Yan Lin, Wenqiang Jiang, Yongfeng Zhao, Siyue Lu, Linghong Miao, Xianping Ge   +7 more
doaj   +1 more source

A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations. [PDF]

Nat Chem, 2017
Busschaert N, Park SH, Baek KH, Choi YP, Park J, Howe ENW, Hiscock JR, Karagiannidis LE, Marques I, Félix V, Namkung W, Sessler JL, Gale PA, Shin I.   +13 more
europepmc   +2 more sources

Dysregulated Erythroid Mg2+ Efflux in Type 2 Diabetes

Frontiers in Cell and Developmental Biology, 2022
Hyperglycemia is associated with decreased Mg2+ content in red blood cells (RBC), but mechanisms remain unclear. We characterized the regulation of Mg2+ efflux by glucose in ex vivo human RBC.
Ana Ferreira, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Seth L. Alper, Jose R. Romero   +6 more
doaj   +1 more source

Ion transport in pigmentation [PDF]

Archives of Biochemistry and Biophysics, 2014
Skin melanocytes and ocular pigment cells contain specialized organelles called melanosomes, which are responsible for the synthesis of melanin, the major pigment in mammals. Defects in the complex mechanisms involved in melanin synthesis and regulation result in vision and pigmentation deficits, impaired development of the visual system, and increased
Nicholas W, Bellono, Elena V, Oancea
openaire   +2 more sources

Cation/Proton Antiporter Genes in Tomato: Genomic Characterization, Expression Profiling, and Co-Localization with Salt Stress-Related QTLs

Agronomy, 2022
The cation/proton antiporter (CPA) family represents a class of transmembrane transporter proteins that play a crucial role in plants during high salinity stress by maintaining the cell’s ionic balance and pH homeostasis.
Zahid Hussain, Habiba Khan, Muhammad Imran, Muhmmad Kashif Naeem, Sabir Hussain Shah, Arshad Iqbal, Syed Shujait Ali, Muhammad Rizwan, Shahid Ali, Muhammad Atif Muneer, Emilie Widemann, Sarfraz Shafiq   +11 more
doaj   +1 more source