Results 41 to 50 of about 125,698 (307)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS3 of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

The Scientific World Journal, 2014
A new approach was recently introduced to improve the structure elucidation power of tandem mass spectrometry simulating the MS3 of ion trap mass spectrometry system overcoming the different drawbacks of the latter.
Ali S. Abdelhameed, Adnan A. Kadi, Hatem A. Abdel-Aziz, Rihab F. Angawi, Mohamed W. Attwa, Khalid A. Al-Rashood   +5 more
doaj   +1 more source

Robust “trapping states” in the motion of a trapped ion [PDF]

Optics Communications, 2004
18 pages, 5 ...
Wallentowitz, S., Vogel, W., Toschek, P. E.   +2 more
openaire   +2 more sources

Dynamic compensation of stray electric fields in an ion trap using machine learning and adaptive algorithm

, 2022
Surface ion traps are among the most promising technologies for scaling up quantum computing machines, but their complicated multi-electrode geometry can make some tasks, including compensation for stray electric fields, challenging both at the level of ...
Ghadimi, Moji, Streed, Erik W., Lobino, Mirko, Shimizu, Kenji, Zappacosta, Alexander, Scarabel, Jordan, Streed, Erik W   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ion Storage Bias and Ion Fragmentation in the Ion Funnel Trap of a Hybrid Ion Mobility Spectrometer/Quadrupole Time-of-Flight Mass Spectrometer

Zhipu Xuebao
In this study, a detailed experimental characterization of the relative ion abundance bias and the ion fragmentation in an ion funnel trap were reported by using both cytochrome C and ubiquitin samples in a tandem ion funnel hybrid ion mobility ...
Zhi-da GUO, Xi-xuan GU, Kai-qun WU, Chen-lu WANG, Jun-hui LI, Jian-cheng YU, Ke-qi TANG   +6 more
doaj   +1 more source

Operation of a planar-electrode ion-trap array with adjustable RF electrodes

New Journal of Physics, 2016
One path to realizing systems of trapped atomic ions suitable for large-scale quantum computing and simulation is to create a two-dimensional (2D) array of ion traps.
M Kumph, P Holz, K Langer, M Meraner, M Niedermayr, M Brownnutt, R Blatt   +6 more
doaj   +1 more source

Two-electrode design for electrostatic ion trap integrable in polar coordinates

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019
Field with additive quadratic dependence on one of coordinates guarantees charged particle motion equation integrability was studied. Ion motion finiteness conditions in electrostatic ion trap are found.
Solovyev Konstantin, Vinogradova Maria
doaj   +1 more source

Methods for structural characterisation of Quillaja saponins by electrospray ionisation ion trap multiple-stage mass spectrometry [PDF]

, 2008
This thesis describes methods for structural classification of Quillaja saponins based on high performance liquid chromatography hyphenated electrospray ionisation ion trap multiple-stage mass spectrometry, in combination with multivariate analysis ...
Bankefors, Johan
core