Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles [PDF]
Bioengineering & Translational Medicine, 2023 Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery ...
Mae M. Lewis +6 more
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Ionizable lipids in bio-inspired nanocarriers. [PDF]
Eur Biophys J, 2023 In applications of bio-inspired nanoparticles (NPs), their composition is often optimised by including ionizable lipids. I use a generic statistical model to describe the charge and potential distributions in lipid nanoparticles (LNPs) containing such ...
Zhdanov VP.
europepmc +5 more sources
Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids [PDF]
Communications BiologyLipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids. However, maintaining the thermostability of mRNA/LNP systems remains challenging. While the importance of only a
Kazuki Hashiba +8 more
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Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids [PDF]
Molecular Therapy: Methods & Clinical DevelopmentIonizable cationic lipids are a critical component of lipid nanoparticles (LNPs), enabling the clinical success of nucleic acid therapeutics through effective encapsulation, delivery, and release.
N. D. Prasad Atmuri +5 more
doaj +2 more sources
Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery [PDF]
Molecules, 2023 Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy.
Yixiang Wang +5 more
doaj +2 more sources
Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery [PDF]
Nature CommunicationsLipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening.
Wei Wang +9 more
doaj +2 more sources
Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature [PDF]
Advanced ScienceTargeted delivery of mRNA with lipid nanoparticles (LNPs) holds great potential for treating pulmonary diseases. However, the lack of rational design principles for efficient lung‐homing lipids hinders the prevalence of mRNA therapeutics in this organ ...
Xiaoyan He +9 more
doaj +2 more sources
High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery [PDF]
Journal of NanobiotechnologyBackground The efficacy of mRNA-based vaccines and therapies relies on lipid nanoparticles (LNPs) as carriers to deliver mRNA into cells. The chemical structure of ionizable lipids (ILs) within LNPs is crucial in determining their delivery efficiency ...
Jingjiao Li +6 more
doaj +2 more sources
Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery. [PDF]
Adv Healthc MaterSafe and functional delivery of delicate mRNA molecules to target tissues is a crucial step in the development of effective vaccines and therapeutic interventions.
Samaridou E +4 more
europepmc +3 more sources
Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs [PDF]
PharmaceuticsBackground/Objectives: Lipid nanoparticles (LNPs) are leading mRNA delivery vehicles, with ionizable lipids (ILs) as their key component. However, the relationship between the IL structure and LNP endogenous organ-targeting is not well understood.
Juan Heredero +19 more
doaj +2 more sources