Results 91 to 100 of about 11,725 (285)
Advanced Functional Materials, EarlyView.PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy +3 more
wiley +1 more source
Structure-based statistical analysis of transmembrane helices [PDF]
, 2013 Recent advances in determination of the high-resolution structure of membrane proteins now enable analysis of the main features of amino acids in transmembrane (TM) segments in comparison with amino acids in water-soluble helices.
A Holt +37 more
core +2 more sources
Advanced Functional Materials, EarlyView.xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat +11 more
wiley +1 more source
Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]
, 2019 The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B +3 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis +19 more
wiley +1 more source
Investigations Into the Influence of Ionizable Lipids on the Stability of Lipid Nanoparticle
MedComm – Biomaterials and ApplicationsMessenger RNA‐loaded lipid nanoparticles (mRNA@LNPs) have achieved remarkable success in vaccine development, but their long‐term preservation imposes stringent requirements for transportation and storage. To broaden application of this technology, it is
Jie Wang +8 more
doaj +1 more source
Charged N-terminus of Influenza Fusion Peptide Facilitates Membrane Fusion [PDF]
, 2018 Cleavage of hemagglutinin precursor (HA0) by cellular proteases results in the formation of two subunits, HA1 and HA2. The N-terminal fragment of HA2, named a fusion peptide (HAfp), possess a charged, amine N-terminus.
Dudek, Anita +4 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji +8 more
wiley +1 more source
Visual Molecular Dynamics Investigations of the Impact of Hydrophobic Nanoparticles on Prognosis of Alzheimer’s Disease and Cancers [PDF]
, 2012 The possible impact of hydrophobic lectin nanoparticles on the prognosis and progression of Alzheimer's disease (AD) and cancers was investigated by Visual Molecular Dynamics (VMD) computer modeling programs available from the Beckmann Advanced ...
I. C. Baianu, M Charles, V. I. Prisecaru
core +1 more source
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling [PDF]
, 2013 Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined cellular uptake of siRNA delivered in
A Akinc +54 more
core +2 more sources