Results 111 to 120 of about 11,725 (285)

Electrostatic Interaction of Heterogeneously Charged Surfaces with Semipermeable Membranes

, 2013
In this paper we study the electrostatic interaction of a heterogeneously charged wall with a neutral semipermeable membrane. The wall consists of periodic stripes, where the charge density varies in one direction.
Lobaskin, Vladimir, Maduar, Salim R., Vinogradova, Olga I.   +2 more
core   +1 more source

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4

npj Vaccines
Ionizable lipid nanoparticles (LNP) that have enabled the success of messenger RNA (mRNA) vaccines have been shown to be immunostimulatory in the absence of mRNA.
Amanda E. Zelkoski, Zhongyan Lu, Gauthaman Sukumar, Clifton Dalgard, Hooda Said, Mohamad-Gabriel Alameh, Edward Mitre, Allison M. W. Malloy   +7 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis

Membranes
Lipid nanoparticles (LNPs) are widely recognized as effective drug delivery systems for RNA therapeutics because their efficacy is critically dependent on structural organization.
Hao Li, Panqi Song, Yiwen Li, Shuyang Tu, Mehwish Mehmood, Liang Chen, Na Li, Qiang Tian   +7 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice

Molecular Therapy: Methods & Clinical Development
Lipid nanoparticles (LNPs) can efficiently deliver nucleic acid therapeutics to a range of tissues, particularly hepatocytes to treat diseases of the liver.
Daniel Stone, Ryo Takeuchi, Harrison Dulin, Michelle A. Loprieno, Daniel E. Strongin, Saraswathi Sathees, Thomas J. Cradick, Martine Aubert, Pavitra Roychoudhury, Jennifer Gordon, Keith R. Jerome   +10 more
doaj   +1 more source

Lipids modulate the conformational dynamics of a secondary multidrug transporter [PDF]

, 2016
Direct interactions with lipids have emerged as key determinants of the folding, structure and function of membrane proteins, but an understanding of how lipids modulate protein dynamics is still lacking.
A Laganowsky, AG Lee, AG Lee, AJ Driessen, Albert Konijnenberg, AM Powl, AM Powl, Aurélie Roth, B Bibal, B Gbaguidi, B Webb, C Bechara, C Hunte, C Koshy, C Lange, C Pliotas, CA Shintre, CC Chen, Chloé Martens, Cédric Govaerts, D Jiang, DP Claxton, EF Pettersen, EG Bligh, F Lanucara, F Sobott, Frank Sobott, FX Contreras, G Fernandez-Ballester, G Heijne, G Jeschke, G Jeschke, G Jeschke, G Khelashvili, G Khelashvili, GW Kaatz, H Bolhuis, H Nury, H Vitrac, Hassane S Mchaourab, I Mierau, IG Denisov, IT Paulsen, JD Thompson, JF Ellena, JJ Ruprecht, JN Sachs, K Adamberg, L Guan, M Kates, M Masureel, M Pannier, M Putman, M Putman, M Putman, M Putman, M Zhou, MA Hanson, Matthieu Masureel, MF Lensink, MM Gottesman, N Fluman, P Hakizimana, P Mazurkiewicz, P Zou, PJ Hamilton, PR Steed, R Dawaliby, R Phillips, RA Stein, Richard A Stein, Rosie Dawaliby, RS Cantor, S Brandon, S Dang, S Mishra, S Pöyry, S Schuldiner, SJ Singer, Smriti Mishra, SS Pao, T Boldog, TA Schaedler, TH Bayburt, TH Haines, TH Haines, W Dowhan, Y Yin   +87 more
core   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases

Acta Pharmaceutica Sinica B
Tailored lipid nanoparticles (LNPs)-mediated small interfering RNA (siRNA) nanomedicines show promise in treating liver disease, such as acute liver injury (ALI) and non-alcoholic steatohepatitis (NASH).
Qiu Wang, Bin Wan, Yao Feng, Zimeng Yang, Dan Li, Fan Liu, Ya Gao, Chang Li, Yanhua Liu, Yongbing Sun, Zhonggui He, Cong Luo, Jin Sun, Qikun Jiang   +13 more
doaj   +1 more source