Results 171 to 180 of about 11,725 (285)

mRNA Vaccines Against SARS-CoV-2 Variants Delivered by Lipid Nanoparticles Based on Novel Ionizable Lipids. [PDF]

Adv Funct Mater, 2022
Chen K, Fan N, Huang H, Jiang X, Qin S, Xiao W, Zheng Q, Zhang Y, Duan X, Qin Z, Liu Y, Zeng J, Wei Y, Song X.   +13 more
europepmc   +1 more source

Ionizable Lipid Nanoparticles Fabrication for Gene Delivery [PDF]

In this project ionizable lipids were analyzed for their efficacy in delivery of mRNA in multiple metastatic lung cancer cells. Different ionizable lipids with their molar ratio in making the LNPs were analyzed in order to enhance the nucleic acid ...
Sparks, Noah, Xu, Lei, Yang, Hu
core   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Erratum: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency. [PDF]

Mol Ther Nucleic Acids
Son J, Yoo H, Park J, Park H, Chong SE, Lee J, Kim J, Park E, Bae SH, Kang S, Ban J, Song S, Oh E, Kwak H, Kwon H, Jung J, Lee N, Jung B, Zhang Y, Kang DD, Du S, Shin YK, Dong Y, Jeong JU.   +23 more
europepmc   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Structure-Activity Relationship of Ionizable Lipids for siRNA and mRNA Lipid Nanoparticle Design. [PDF]

ACS Biomater Sci Eng
Lee SM, Sun Y, Chatterjee S, Xiong H, Cheng Q, Wang X, Siegwart DJ.   +6 more
europepmc   +1 more source

Pharmacokinetic principles [PDF]

, 2006
De Paepe, Peter, Kalmar, Alain, Struys, Michel   +2 more
core   +1 more source

Efficient Preservation of Perishable Fruits by Erasable Metal‐Organic Frameworks

Advanced Science, EarlyView.
This study presents an erasable Pickering emulsion‐based coating stabilized by metal‐organic frameworks. This washable coating significantly extends fruit shelf life by scavenging ethylene and inhibiting foodborne pathogens, offering a sustainable solution for postharvest.
Liying Yang, Jia Kong, Haoran Bai, Xiaojie Wu, Douxin Xiao, Ming Du, Peng Yang, Alideertu Dong   +7 more
wiley   +1 more source

Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency. [PDF]

Mol Ther Nucleic Acids
Son J, Yoo H, Park J, Park H, Chong SE, Lee J, Kim J, Park E, Bae SH, Kang S, Ban J, Song S, Oh E, Kwak H, Kwon H, Jung J, Lee N, Jung B, Zhang Y, Kang DD, Du S, Shin YK, Dong Y, Jeong JU.   +23 more
europepmc   +1 more source