Ionizable Lipid Nanoparticles for mRNA Delivery
Advanced NanoBiomed Research, 2023 Therapeutics based on messenger RNA (mRNA) have become a promising class of methods for various diseases’ treatments in recent years. The safe and effective delivery of mRNA into target cells is the premise of the clinical translation of mRNA. Due to the
Xuefeng Tang, Ying Zhang, Xiaojun Han
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Modulating the Nature of Ionizable Lipids and Number of Layers in Hyaluronan-Decorated Lipid Nanoparticles for In Vitro Delivery of RNAi [PDF]
PharmaceuticsLipid nanoparticles (LNPs) have established their position as nonviral vectors for gene therapy. Tremendous efforts have been made to modulate the properties of LNPs to unleash their full clinical potential.
Victor Passos Gibson +6 more
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Spotlighting the criticality of lipid quality control through a mechanistic investigation of mRNA activity loss in lipid nanoparticles [PDF]
Communications ChemistryLipid nanoparticles (LNPs) have gained much attention after the recent launch of mRNA based Covid vaccines. For mRNA encapsulated within LNPs to be successfully translated into target proteins, the mRNA must maintain its integrity and also be free of any
Richard S. Kang +5 more
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Carbon dot-lipidoid nanocarriers for superiorly biocompatible nasal mRNA cancer vaccination [PDF]
Journal of NanobiotechnologyIn this study, we synthesized an ionizable lipidoid, Cdoids, composed of carbon dots (Cdots) conjugated with oleic acid that exhibits superior biocompatibility compared to conventional ionizable lipids while retaining intrinsic fluorescence for real-time
Hongjae Kim +7 more
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Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery. [PDF]
J Control Release, 2023 Lipid nanoparticles (LNPs) have delivered siRNA and mRNA drugs in humans, underscoring the potential impact of improving the therapeutic window of next-generation LNPs. To increase the LNP therapeutic window, we applied lessons from small-molecule chemistry to ionizable lipid design.
Da Silva Sanchez AJ +11 more
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An ionizable lipid toolbox for RNA delivery [PDF]
Nature Communications, 2021 Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
Xuexiang Han +6 more
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Boosting ribosomal translation via ionizable lipid-hydrogel microplexes for localized mRNA therapy [PDF]
Bioactive MaterialsmRNA therapy holds immense promise for regenerative medicine; however, localized endoplasmic reticulum stress (ERS) in damaged tissues can impair the critical process of ribosomal translation.
Yanyang Chen +7 more
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Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA [PDF]
Small Science, 2023 Kazuki Hashiba +9 more
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Calculating Apparent pKa Values of Ionizable Lipids in Lipid Nanoparticles. [PDF]
Mol PharmCreating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent pKa value of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for the prediction of the apparent pKa value of ...
Hamilton NB +4 more
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mRNA vaccine developed for sequential selective organ-to-cell targeting of glioma [PDF]
Nature CommunicationsMessenger RNA (mRNA)-based therapeutics hold great potential for effectively treating various diseases. However, the targeting of mRNA delivered by systemically administered lipid nanoparticles (LNP) is currently limited to the liver.
Lin Shi +7 more
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