Recent advances in lipid nanoparticles for cancer vaccine delivery: Challenges and future perspectives. [PDF]
Int J Pharm XHasan N +8 more
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Clinical Pharmacology &Therapeutics, EarlyView.Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz +15 more
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Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
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Physiological Barriers to Nucleic Acid Therapeutics and Engineering Strategies for Lipid Nanoparticle Design, Optimization, and Clinical Translation. [PDF]
PharmaceuticsKim Y +9 more
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Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives. [PDF]
MedComm (2020)Li X +7 more
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Artificial intelligence-guided design of lipid nanoparticles for mRNA delivery. [PDF]
Acta Pharm Sin BSu K, Qiu J, Xu T, Liu S.
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Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated. [PDF]
Mol Ther Methods Clin DevHe Y +6 more
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A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles
Journal of Materials Chemistry B, 2023The combination of ionizable lipids bearing alkyl chains and fluorinated alkyl chains improves the cellular uptake and mRNA expression of lipid nanoparticles.
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Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
Journal of the American Chemical Society, 2023Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends on the inclusion of an ionizable lipid, and small changes to these lipid structures can significantly improve delivery ...
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Action of ionizing radiation on lipid-protein interaction
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