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Analysis of Lipids: Metal Oxide Laser Ionization Mass Spectrometry
Analytical Chemistry, 2012Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been used for lipid analysis; however, one of the drawbacks of this technique is matrix interference peaks at low masses. Metal oxide surfaces are described here for direct, matrix-free analysis of small (MW < 1000 Da) lipid compounds, without interferences in the resulting ...
Casey R, McAlpin +3 more
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The effect of ionizing radiation on lipid membranes
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1991Contrary to previous reviews, which provide a general survey about radiation effects on biomembranes, the present article concentrates on the lipid component. Two main objectives are envisaged: Radiation induced modification of membrane transport and the «inverse dose rate effect»
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Ionizable Lipids from Click Reactions for Lipid Nanoparticle Assembling and mRNA Delivery
The Journal of Physical Chemistry BIonizable lipid-containing lipid nanoparticles (LNPs) are regarded as promising nonviral vectors for gene therapy delivery systems. Rationale design of the ionizable lipid structure based on initial screening of ionizable lipid molecule libraries combined with systematic comparison and analysis on the physical chemical parameters related to delivery ...
Feiyang Xu +7 more
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Microcolumn liquid analysis of lipids with flame ionization detection
Journal of the American Oil Chemists' Society, 1967AbstractA system for the rapid analysis of compounds which may be either too large or too sensitive to be subjected intact to gas chromatographic or other methods is described. Capillary columns of 0.5 mm and 1 mm I.D. and various lengths are packed with very fine particle size, specially prepared, silica gel and other media.
J E, Stouffer, P L, Oakes
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Ionizing Radiation, Atherosclerosis, and Lipid Metabolism in Pigeons
Radiation Research, 1965The present investigations were suggested by the hypothesis that ionizing radiations may play a role in the development of atherosclerosis. Indeed, in both human subjects and experimental animals, this disease is more or less closely associated with aging; and, in turn, the life-shortening effect of radiation has been often interpreted as an ...
C, Artom, H B, Lofland, T B, Clarkson
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A Cell-Free Kinetic Analysis of Ionizable Lipid Hydrolysis
Analytical ChemistryThe prolonged retention of ionizable lipids within the body limits the repeated dosing of lipid nanoparticles (LNPs) for nucleic acid delivery. While most ionizable lipids are primarily metabolized in the liver via the enzymatic hydrolysis of ester bonds, elimination half-lives can range from several hours to days.
Julien Couture-Senécal +2 more
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International Journal of Pharmaceutics, 2016
Lipid nanoparticles (LNPs) represent the most advanced platform for the systemic delivery of siRNA. We have previously reported the discovery of novel ionizable lipids with asymmetric lipid tails, enabling potent gene-silencing activity in hepatocytes in vivo; however, the structure and delivery mechanism had not been elucidated.
Yuta, Suzuki, Hiroshi, Ishihara
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Lipid nanoparticles (LNPs) represent the most advanced platform for the systemic delivery of siRNA. We have previously reported the discovery of novel ionizable lipids with asymmetric lipid tails, enabling potent gene-silencing activity in hepatocytes in vivo; however, the structure and delivery mechanism had not been elucidated.
Yuta, Suzuki, Hiroshi, Ishihara
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Polysorbate 80-containing ionizable lipid nanoparticles for mRNA delivery
Biomaterials ScienceCompared to PEG-iLNPs, PS80-iLNPs showed a 1.14-fold increase in stealthiness, 1.12 times higher cell viability and superior protein adsorption resistance.
Xuefeng Tang +6 more
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Lipid Nanoparticles-Mediated mRNA Delivery to the Eye Affected by Ionizable Cationic Lipid
Molecular PharmaceuticsIonizable lipid serves as the key functional component in lipid nanoparticles (LNPs) for efficient mRNA delivery. This study aims to systematically evaluate clinically approved ionizable lipid DLin-MC3-DMA and SM102-based LNPs for ocular mRNA delivery, with a comprehensive assessment of their physicochemical characteristics, delivery efficiency, and ...
Siyu Dong +11 more
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TLR7-Adjuvanted Ionizable Lipid Nanoparticles for mRNA Vaccine Delivery
The AAPS JournalIonizable lipid nanoparticles (LNPs) are clinically relevant non-viral vectors that allow intracellular delivery of mRNA vaccines to immune cells. To fight against notorious pathogens and cancer, mRNA vaccines necessitate the addition of an adjuvant to induce strong and durable cell-mediated immune responses. Adjuvants that stimulate Toll-like receptor
Bishal Misra +5 more
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