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Synthesis of novel cholesterol-based ionizable lipids for mRNA delivery
Colloids and Surfaces B: BiointerfacesThe safe and effective delivery of messenger ribonucleic acid (mRNA) is crucial for its therapeutic effects in vivo. In this study, we developed a new type of ionizable lipid S-1, which contains an amino head, a cholesterol matrix, and a long hydrophobic carbon tail. We employed microfluidics to rapidly mix an ethanol phase containing S-1 lipid with an
Rui Qian +6 more
openaire +2 more sources
Neurotoxic reactive astrocytes induce cell death via saturated lipids
Nature, 2021Kevin A Guttenplan +2 more
exaly
Biological, clinical and population relevance of 95 loci for blood lipids
Nature, 2010Kiran Musunuru +2 more
exaly
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Chemical Reviews, 2019Paolo Di Mascio +2 more
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Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Journal of Physical Chemistry B, 2010Jeffery B Klauda +2 more
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Lipids in exosomes: Current knowledge and the way forward
Progress in Lipid Research, 2017Tore Skotland +2 more
exaly
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Nature Reviews Drug Discovery, 2007Natalie L Trevaskis
exaly
The effects of ionizing radiation on lipids
Progress in the Chemistry of Fats and other Lipids, 1973openaire +1 more source