Results 21 to 30 of about 11,725 (285)

CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids [PDF]

Journal of Chemical Information and Modeling, 2021
ABSTRACTA lipid nanoparticle (LNP) formulation is a state-of-the-art delivery system for genetic drugs such as DNA, mRNA, and siRNA, which is successfully applied to COVID-19 vaccines and gains tremendous interest in therapeutic applications. Despite its importance, a molecular-level understanding of the LNP structures and dynamics is still lacking ...
Soohyung Park, Yeol Kyo Choi, Seonghoon Kim, Jumin Lee, Wonpil Im   +4 more
openaire   +3 more sources

Ionizable lipid nanoparticles for in utero mRNA delivery [PDF]

Science Advances, 2021
Lipid nanoparticles deliver mRNA to mouse fetuses, which may ultimately enable in utero therapy to treat fetal genetic diseases.
Rachel S. Riley, Meghana V. Kashyap, Margaret M. Billingsley, Brandon White, Mohamad-Gabriel Alameh, Sourav K. Bose, Philip W. Zoltick, Hiaying Li, Rui Zhang, Andrew Y. Cheng, Drew Weissman, William H. Peranteau, Michael J. Mitchell   +12 more
openaire   +3 more sources

Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery. [PDF]

ACS Nano
Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and providing an alternative approach to gene therapy without the drawbacks associated with viral delivery.
Isaac I, Shaikh A, Bhatia M, Liu Q, Park S, Bhattacharya C.   +5 more
europepmc   +3 more sources

Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery

Pharmaceutics, 2023
Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs.
Zhigao Shen, Cong Liu, Ziqian Wang, Fengfei Xie, Xingwu Liu, Lingkai Dong, Xuehua Pan, Chen Zeng, Peng George Wang   +8 more
doaj   +1 more source

Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines

Vaccines, 2023
Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery.
K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava, Haitao Hu, Srinivasa Reddy Bonam, Rajendra Kurapati   +7 more
doaj   +1 more source

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach [PDF]

Langmuir, 2021
Lipid nanoparticles (LNPs) containing short-interfering RNA (LNP-siRNA systems) are a promising approach for silencing disease-causing genes in hepatocytes following intravenous administration. LNP-siRNA systems are generated by rapid mixing of lipids in ethanol with siRNA in aqueous buffer (pH 4.0) where the ionizable lipid is positively charged ...
Takeshi Terada, Jayesh A. Kulkarni, Ariel Huynh, Sam Chen, Roy van der Meel, Yuen Yi C. Tam, Pieter R. Cullis   +6 more
openaire   +3 more sources

In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Nanomaterials, 2022
Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids.
Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, Federico Perche   +5 more
doaj   +1 more source

mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles

Current Protocols, 2023
AbstractmRNA vaccines have recently generated significant interest due to their success during the COVID‐19 pandemic. Their success is due to advances in mRNA design and encapsulation into ionizable lipid nanoparticles (iLNPs). This has highlighted the potential for the use of mRNA‐iLNPs in other settings such as cancer, gene therapy, or vaccines for ...
McKenzie, Rebecca Elizabeth, Minnell, Jordan James, Ganley, Mitch, Painter, Gavin Frank, Draper, Sarah   +4 more
openaire   +2 more sources

New ionizable lipids reduce the lipid-to-mRNA ratio for base editing. [PDF]

Natl Sci Rev
Gao S, Xu Q.
europepmc   +3 more sources

Lipid nanoparticles with ionizable lipids: Statistical aspects

Physical Review E, 2022
Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
openaire   +2 more sources