Lipid nanoparticles employed in mRNA-based COVID-19 vaccines: An overview of materials and processes used for development and production [PDF]
Arhiv za farmaciju, 2022 In the light of the recommended application of the third dose, both public and professional community would benefit from a detailed report on the technological advances behind the developed messenger ribonucleic acid (mRNA) based COVID-19 vaccines ...
Pantelić Ivana +3 more
doaj +1 more source
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Bioengineering & Translational Medicine, 2021 Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches ...
Michele Schlich +6 more
doaj +1 more source
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm
Acta Pharmaceutica Sinica B, 2022 Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time.
Wei Wang +5 more
doaj +1 more source
Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing [PDF]
, 2012 The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices,
Carlos Baeza-Delgado +6 more
core +4 more sources
Electrostatic Repulsion of Positively Charged Vesicles and Negatively Charged Objects [PDF]
, 1999 A positively charged, mixed bilayer vesicle in the presence of negatively charged surfaces (for example, colloidal particles) can spontaneously partition into an adhesion zone of definite area, and another zone that repels additional negative objects ...
Aranda-Espinoza, Helim +6 more
core +6 more sources
A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery
Advanced Science, 2023 Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel ...
Gonna Somu Naidu +10 more
doaj +1 more source
The influence of the polar head-group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain [PDF]
, 2016 The development of novel non-viral delivery vehicles is essential in the search of more efficient strategies for retina and brain diseases. Herein, optimized niosome formulations prepared by oil-in water (o/w) and film-hydration techniques were ...
Agirre, Mireia +11 more
core +1 more source
Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]
, 2014 Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona +6 more
core +3 more sources
Frontiers in Molecular Biosciences, 2022 In silico prediction of the in vivo efficacy of siRNA ionizable-lipid nanoparticles is desirable as it can save time and resources dedicated to wet-lab experimentation. This study aims to computationally predict siRNA nanoparticles in vivo efficacy.
Abdelkader A. Metwally +4 more
doaj +1 more source
Niosomes based on synthetic cationic lipids for gene delivery: The influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells [PDF]
, 2015 We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency. These lipids were characterized by small-angle X-ray scattering before being incorporated into the niosomes ...
Agirre, Mireia +10 more
core +1 more source