Results 41 to 50 of about 11,725 (285)

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V, Kelly, John M, Meyer, David J, Miles, Michael A, Taylor, Martin C, Wilkinson, Shane R   +5 more
core   +4 more sources

Correction to "Calculating Apparent p<i>K</i>_a Values of Ionizable Lipids in Lipid Nanoparticles". [PDF]

Mol Pharm
This document is a correction to our paper: Calculating Apparent pKa Values of Ionizable Lipids in Lipid Nanoparticles, Mol. Pharmaceutics 2025, 22, 1, 588–593. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c00426 (also posted on ChemRxiv:https://chemrxiv.org/engage/chemrxiv/article-details/6605d0cd9138d23161947865). Equation 1 included a term kT
Hamilton NB, Arns S, Shelley M, Bechis I, Shelley JC.   +4 more
europepmc   +2 more sources

Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function

Nanoscale, 2019
The distribution of ionizable amino lipids (KC2) is critical in structure of lipid nanoparticles, siRNA entrapment and endosomal release. Neutral KC2 segregates from phospholipids (POPC) and forms an oily core in the bilayer interior.
M. Ramezanpour, M. L. Schmidt, I. Bodnariuc, J. A. Kulkarni, S. S. W. Leung, P. R. Cullis, J. L. Thewalt, D. P. Tieleman   +7 more
openaire   +2 more sources

Detergents and Chaotropes for Protein Solubilization before Two-Dimensional Electrophoresis [PDF]

, 2006
Because of the outstanding separating capabilities of two-dimensional electrophoresis for complete proteins, it would be advantageous to be able to apply it to all types of proteins.
Chevallet, Mireille, Luche, Sylvie, Rabilloud, Thierry, Santoni, Véronique   +3 more
core   +4 more sources

Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance. [PDF]

ACS Nano
The advent of mRNA for nucleic acid (NA) therapeutics has unlocked many diverse areas of research and clinical investigation. However, the shorter intracellular half-life of mRNA compared with other NAs may necessitate more frequent dosing regimens. Because lipid nanoparticles (LNPs) are the principal delivery system used for mRNA, this could lead to ...
Holland R, Lam K, Jeng S, McClintock K, Palmer L, Schreiner P, Wood M, Zhao W, Heyes J.   +8 more
europepmc   +3 more sources

Asymmetric protonation of EmrE [PDF]

, 2015
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-site” residues—glutamate 14 (Glu14) from each subunit—must be poised
Adam, Anne E. Robinson, Bay, Castañeda, Chen, Chill, Delaglio, Emma A. Morrison, Farrell, Grimsley, Hu, Hu, Katherine A. Henzler-Wildman, Lehner, Li, Lindman, Mager, McIntosh, Morrison, Morrison, Morrison, Muth, Nagai, Nielsen, Oxenoid, Pace, Pellecchia, Platzer, Reijenga, Rotem, Shrager, Smirnova, Smith, Soskine, Tomlinson, Vranken, Webb, Weinglass, Wüthrich, Yerushalmi, Yerushalmi, Yerushalmi, Yongjia Liu   +42 more
core   +2 more sources

Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids

Pharmaceutics, 2023
Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and ...
Juncheng Lu, Elena N. Atochina-Vasserman, Devendra S. Maurya, Muhammad Irhash Shalihin, Dapeng Zhang, Srijay S. Chenna, Jasper Adamson, Matthew Liu, Habib Ur Rehman Shah, Honey Shah, Qi Xiao, Bryn Queeley, Nathan A. Ona, Erin K. Reagan, Houping Ni, Dipankar Sahoo, Mihai Peterca, Drew Weissman, Virgil Percec   +18 more
doaj   +1 more source

Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density

, 2015
The electrostatic complexation between DOTAP-DOPC unilamellar liposomes and an oppositely charged polyelectrolyte (NaPA) has been investigated in a wide range of the liposome surface charge density.
Bordi, Federico, Carlini, Laura, Sennato, Simona, Truzzolillo, Domenico   +3 more
core   +3 more sources

Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes. [PDF]

, 2015
The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools.
Gu, Li, Kholodovych, Vladyslav, Martin, Adriana AT, Moghe, Prabhas V, Murthy, N Sanjeeva, Sommerfeld, Sven Daniel, Tomasini, Michael, Uhrich, Kathryn E, Welsh, William J   +8 more
core   +2 more sources

Electrospray ionization mass spectrometry of lysoglycerophosphocholine lipid subclasses.

Journal of the American Society for Mass Spectrometry, 2000
Lysoglycerophosphocholine lipids (lyso-GPC) are important intermediates in the synthesis and metabolism of glycerophosphocholine lipids which are major components of the cellular lipid bilayer. Significant differences in the collisional induced decomposition (CID) behavior were observed for each of the four different subtypes of lyso-GPC in both ...
Khaselev, Nona, Murphy, Robert C
openaire   +2 more sources