Results 51 to 60 of about 11,725 (285)
Mass spectrometric imaging of lipids using desorption electrospray ionization [PDF]
Journal of Chromatography B, 2009 Desorption electrospray ionization (DESI), a relatively new ambient ionization technique used in mass spectrometry (MS), allows for the direct analysis of samples such as thin tissue sections, to be conducted outside of vacuum in the ambient environment and often without sample preparation.
Allison L, Dill +4 more
openaire +2 more sources
Acta Pharmaceutica Sinica BThe lipid nanoparticle (LNP) has been so far proven as a strongly effective delivery system for mRNA and siRNA. However, the mechanisms of LNP's distribution, metabolism, and elimination are complicated, while the transportation and pharmacokinetics (PK)
Wei Wang +3 more
doaj +1 more source
Pharmaceuticals, 2023 In biomedical applications, nanomaterial-based delivery vehicles, such as lipid nanoparticles, have emerged as promising instruments for improving the solubility, stability, and encapsulation of various payloads.
Tetiana Korzun +7 more
doaj +1 more source
Modulation of elasticity and interactions in charged lipid multibilayers: monovalent salt solutions
, 2016 We have studied the electrostatic screening effect of NaCl solutions on the interactions between anionic lipid bilayers in the fluid lamellar phase using a Poisson-Boltzmann based mean-field approach with constant charge and constant potential limiting ...
Belička, Michal +4 more
core +3 more sources
Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery
European Journal of Pharmaceutical SciencesLipid nanoparticles (LNPs) are successfully used for RNA-based gene delivery. In the context of gene replacement therapies, however, delivery of DNA expression plasmids using LNPs as a non-viral vector could be a promising strategy for the induction of longer-lasting effects.
Claudia Lotter +8 more
openaire +2 more sources
Sporopollenin, the least known yet toughest natural biopolymer [PDF]
, 2015 © 2015 Mackenzie, Boa, Diego-Taboada, Atkin and Sathyapalan. Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen, and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 million ...
Atkin, Stephen L. +5 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability
npj Vaccines, 2023 During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but several key ...
Lizhou Zhang +9 more
doaj +1 more source
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and [PDF]
, 2018 Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks.
Anderson, Daniel Griffith +11 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source