Results 61 to 70 of about 11,725 (285)

Atherogenic lipid fractions are related to ionized magnesium status [PDF]

The American Journal of Clinical Nutrition, 1998
The plasma concentration of ionized magnesium (iMg++), the serum total magnesium concentration (tMg), and lipoprotein status were assessed in 29 elderly men with impaired insulin sensitivity but who were otherwise healthy and not receiving antidiabetic pharmacologic treatment.
A, Haenni, M, Ohrvall, H, Lithell
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy

Pharmaceutics, 2023
Lipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LNP structure and
Christoph Wilhelmy, Isabell Sofia Keil, Lukas Uebbing, Martin A. Schroer, Daniel Franke, Thomas Nawroth, Matthias Barz, Ugur Sahin, Heinrich Haas, Mustafa Diken, Peter Langguth   +10 more
doaj   +1 more source

Ion Induced Lamellar-Lamellar Phase Transition in Charged Surfactant Systems

, 2006
We propose a model for the liquid-liquid phase transition observed in osmotic pressure measurements of certain charged lamellae-forming amphiphiles.
Andelman, David, Harries, Daniel, Mar-Or, Etay, Parsegian, V. Adrian, Podgornik, Rudi   +4 more
core   +1 more source

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]

, 2013
The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire, Clapham, D.E., DeCaen, P.G., Delling, M., McCusker, Emily C., Ulmschneider, J.P., Ulmschneider, Martin B., Wallace, Bonnie A.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery

Nature Communications
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types.
Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li   +12 more
doaj   +1 more source

Advances in the delivery of RNA therapeutics: from concept to clinical reality [PDF]

, 2017
- The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the ...
Anderson, Daniel Griffith, Kaczmarek, James Cliff, Kowalski, Piotr S   +2 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Ion-Specific Hydration Effects: Extending the Poisson-Boltzmann Theory

, 2011
In aqueous solutions, dissolved ions interact strongly with the surrounding water, thereby modifying the solution properties in an ion-specific manner. These ion-hydration interactions can be accounted for theoretically on a mean-field level by including
Andelman, David, Ben-Yaakov, Dan, Harries, Daniel, Podgornik, Rudi   +3 more
core   +1 more source