Results 71 to 80 of about 11,725 (285)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics

Frontiers in Pharmacology, 2022
The messenger RNA (mRNA) vaccines for COVID-19, Pfizer-BioNTech and Moderna, were authorized in the US on an emergency basis in December of 2020. The rapid distribution of these therapeutics around the country and the world led to millions of people ...
Adonis Sfera, Adonis Sfera, Sabine Hazan, Jonathan J. Anton, Jonathan J. Anton, Dan O. Sfera, Christina V. Andronescu, Sarvin Sasannia, Leah Rahman, Zisis Kozlakidis   +9 more
doaj   +1 more source

Spatial variations in the molecular diversity of dissolved organic matter in water moving through a boreal forest in eastern Finland [PDF]

, 2017
201
Finér, Leena, Fujitake, Nobuhide, Hara, Miyako, Ide, Jun'ichiro, Kortelainen, Pirkko, Moritani, Mina, Ohashi, Mizue, Ohte, Nobuhito, Piirainen, Sirpa, Sugiyama, Yuko, Takahashi, Katsutoshi, Yamase, Keitaro   +11 more
core   +2 more sources

Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications

Advanced Materials, 2023
Lipid nanoparticles (LNPs) have proven a successful platform for the delivery of nucleic acid (NA)-based therapeutics and vaccines, with the ionizable lipid component playing a key role in modulating potency and tolerability. Here, a library of 16 novel ionizable lipids is screened hypothesizing that short, branched trialkyl hydrophobic domains can ...
Kieu Lam, Ada Leung, Alan Martin, Mark Wood, Petra Schreiner, Lorne Palmer, Owen Daly, Wenchen Zhao, Kevin McClintock, James Heyes   +9 more
openaire   +2 more sources

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Molecular Factors Influencing Retention on Immobilized Artificial Membranes (IAM) Compared to Partitioning in Liposomes and n -Octanol [PDF]

, 2018
Purpose. To assess the effect of molecular factors influencing retention on immobilized artificial membrane (IAM) high-performance liquid chromatography columns compared to liposomal partitioning and traditional n-octanol/water partition coefficients ...
Caron, Giulia, Carrupt, Pierre-Alain, Fruttero, Roberta, Martinet, Catherine, Reist, Marianne, Taillardat-Bertschinger, Agnes, Testa, Bernard   +6 more
core  

Comparison of lipid membrane-water partitioning with various organic solvent-water partitions of neutral species and ionic species: Uniqueness of cerasome as a model for the stratum corneum in partition processes [PDF]

, 2015
YesLipid membrane-water partitions (e.g., immobilized artificial membrane systems where the lipid membrane is a neutral phospholipid monolayer bound to gel beads) were compared to various organic solvent-water partitions using linear free energy ...
Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Alfred Fahr, Austin, Avdeef, Balon, Balon, Bano, Beigi, Carrozzino, Collander, Desmond J. Tobin, Finkelstein, Fruttero, Ishihama, Keda Zhang, Leo, Liu, Liu, Lukacova, Mason, Meindl, Michael H. Abraham, Moore, Ong, Ong, Osterberg, Pauletti, Pidgeon, Rand, Sarmento, Tejwani, Wiedmer, Wiedmer, William E. Acree, Xiang, Xiangli Liu, Zhang, Zhang   +49 more
core   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Machine learning techniques for lipid nanoparticle formulation

Nano Convergence
A significant amount of effort has been poured into optimizing the delivery system that is demanded by novel therapeutic modalities. Lipid nanoparticle presents as a solution to transfect cells safely and efficiently with nucleic acid-based therapeutics.
Hao Li, Yayi Zhao, Chenjie Xu
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source