Results 81 to 90 of about 11,725 (285)
Scientific ReportsThis study utilized all-atom molecular dynamics (MD) simulations to investigate the interactions and driving forces involved in the formation of mRNA-containing lipid nanoparticles (LNPs) at acidic pH (4.5) and physiological pH.
Ari Hardianto +5 more
doaj +1 more source
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Nature Communications, 2019 Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via
Marco Maugeri +17 more
doaj +1 more source
Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core +2 more sources
Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery
Small ScienceAntimicrobial resistance (AMR) poses a global health crisis demanding innovative solutions. Traditional antibiotics, though pivotal over the past century in combating bacterial infections, face diminished efficacy against evolving bacterial defense mechanisms, especially in Gram‐negative strains.
Haitao Yu +9 more
openaire +3 more sources
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA [PDF]
ACS Nano, 2018 Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the mechanism of formation and certain structural features of LNP-siRNA remain obscure.
Jayesh A. Kulkarni +7 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu +3 more
wiley +1 more source
Biological insertion of computationally designed short transmembrane segments [PDF]
, 2016 The great majority of helical membrane proteins are inserted co-translationally into the ER membrane through a continuous ribosome-translocon channel. The efficiency of membrane insertion depends on transmembrane (TM) helix amino acid composition, the ...
Baeza Delgado, Carlos +3 more
core +3 more sources
Advanced Functional Materials, EarlyView.Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird +8 more
wiley +1 more source
Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution [PDF]
, 2018 The measurement of physicochemical properties at an early phase of drug discovery and development is crucial to reduce attrition rates due to poor biopharmaceutical properties.
Bard, Bruno +5 more
core
Phase Coexistence in Single-Lipid Membranes Induced by Buffering Agents [PDF]
, 2014 Recent literature has shown that buffers affect the interaction between lipid bilayers through a mechanism that involves van der Waals forces, electrostatics, hydration forces and membrane bending rigidity.
Johnson, Merrell A. +3 more
core +2 more sources