A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Current-voltage characteristic of parallel-plane ionization chamber with inhomogeneous ionization
, 2007 The balances of particles and charges in the volume of parallel-plane ionization chamber are considered. Differential equations describing the distribution of current densities in the chamber volume are obtained. As a result of the differential equations
A.R. Smith +7 more
core +1 more source
The different origins of high- and low-ionization broad emission lines revealed by gravitational microlensing in the Einstein cross [PDF]
, 2016 We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high- and low-ionization broad emission lines.
Anguita, Timo +3 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Modulated voltage metastable ionization detector [PDF]
, 1985 The output current from a metastable ionization detector (MID) is applied to a modulation voltage circuit. An adjustment is made to balance out the background current, and an output current, above background, is applied to an input of a strip chart ...
Carle, G. C. +2 more
core +1 more source
Coincidence spectroscopy of high-lying Rydberg states produced in strong laser fields
, 2016 We report on the measurement of electron emission after the interaction of strong laser pulses with atoms and molecules. These electrons originate from high-lying Rydberg states with quantum numbers up to $n \lesssim 120$ formed by frustrated field ...
Baltuška, Andrius +9 more
core +1 more source
Field dependence of impact ionization coefficients in In0.53Ga0.47As [PDF]
, 2003 Electron and hole ionization coefficients in In/sub 0.53/Ga/sub 0.47/As are deduced from mixed carrier avalanche photomultiplication measurements on a series of p-i-n diode layers, eliminating other effects that can lead to an increase in photocurrent ...
David, J.P.R. +4 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Kinetic evaluation of the solvolysis of isobutyl chloro- and chlorothioformate esters
Beilstein Journal of Organic Chemistry, 2011 The specific rates of solvolysis of isobutyl chloroformate (1) are reported at 40.0 °C and those for isobutyl chlorothioformate (2) are reported at 25.0 °C, in a variety of pure and binary aqueous organic mixtures with wide ranging nucleophilicity and ...
Malcolm J. D’Souza +4 more
doaj +1 more source
Double ionization of a three-electron atom: Spin correlation effects
, 2019 We study the effects of spin degrees of freedom and wave function symmetries on double ionization in three-electron systems. Each electron is assigned one spatial degree of freedom.
Eckhardt, Bruno +4 more
core +1 more source