Results 71 to 80 of about 41,324 (250)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

Gramicidin A: A New Mission for an Old Antibiotic

open access: yesJournal of Kidney Cancer and VHL, 2015
Gramicidin A (GA) is a channel-forming ionophore that renders biological membranes permeable to specific cations which disrupts cellular ionic homeostasis.
Justin M David, Ayyappan K Rajasekaran
doaj   +1 more source

Ionophore-based ion-selective potentiometric and optical sensors [PDF]

open access: yes, 2003
This paper describes ion-selective electrodes (ISEs) and optodes with a focus on the fundamental mechanisms, response characteristics, and recognition elements (ionophores) described to date for these sensors.
Johnson, R Daniel, Bachas, Leonidas G
core   +1 more source

Pyridine Acyl Thiourea as Ionophore for the Detection of Copper(II) in Aqueous Phase [PDF]

open access: yes, 2016
Copper(II) ion chemical sensor based on acyl pyridine thiourea derivative featuring N-pyridyl-N’-(butyryl)thiourea (PT1) was successfully synthesised, characterised, and investigated as ionophore in the form of thin-film PVC membrane.
Khairul, Wan M.   +3 more
core   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo   +9 more
wiley   +1 more source

Induction of Acrosome Reaction by Calcium Ionophore A23187 in Sperm Separated by Two-layer Percoll Gradient Method

open access: yesSiriraj Medical Journal, 2003
The aim of this study was to compare thepercentages of sperm with an acrosome reaction between those with and without calcium ionophore A23187 induction after two-layer Percoll gradient separation.
Roungsin Choavaratana   +3 more
doaj  

Ionophore effects on animal metabolism [PDF]

open access: yes, 1987
Typescript (photocopy).Studies were conducted to determine the effects of ionophores, diet, level of intake and dietary restriction on vital organ mass and hepatic fructose 2,6-bisphosphate (F26P2) levels in growing non-ruminants and ionophores on vital ...
Benz, Daniel Arthur
core  

Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms. [PDF]

open access: yes, 1989
Pial arterioles on the surface of the mouse brain were observed in vivo under a chamber with a glass window. When placed under the window, calcium ionophore, acetylcholine, and previously acidified sodium nitrite each dilated the arterioles.
W I Rosenblum, B Wormley, M McDonald
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

open access: yesBMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang   +6 more
wiley   +1 more source

Antimicrobial supplementation alters digestibility and ruminal fermentation in a continuous culture model

open access: yesJournal of Applied Animal Research, 2021
A dual-flow continuous culture system was used to evaluate the effects of laidlomycin propionate and bacitracin zinc on fermentation, nutrient digestibility, and microbial efficiency. Factors were laidlomycin propionate (LP; 2 mg/L of culture volume) and
Alex J. Thompson   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy