Results 61 to 70 of about 63,777 (241)

Ionophores

open access: yes, 2006
This revised and expanded reference is a valuable aid for the practicing veterinary clinician in diagnosing and determining treatment for toxic exposures in small animals, and for veterinary students as a supplement to their classroom instruction. It contains chapters addressing nontraditional areas of toxicology not covered in conventional toxicology ...
openaire   +2 more sources

A Reliable and Non-destructive Method for Monitoring the Stromal pH in Isolated Chloroplasts Using a Fluorescent pH Probe

open access: yesFrontiers in Plant Science, 2017
The proton gradient established by the pH difference across a biological membrane is essential for many physiological processes, including ATP synthesis and ion and metabolite transport.
Pai-Hsiang Su   +2 more
doaj   +1 more source

Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease [PDF]

open access: yes, 2015
Funding: The Scottish Government funded this work, as part of their global budget on aquaculture research. The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Collet, Bertrand   +6 more
core   +3 more sources

Squalamine is not a proton ionophore

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2000
Squalamine, an aminosterol antibiotic isolated from the dogfish shark, creates relatively large defects in phospholipid bilayers, allowing the unrestricted translocation of small molecules across these compromised membranes (B.S. Selinsky, Z. Zhou, K.G. Fotjik, S. R. Jones, N.R. Dollahon, A.E. Shinnar, Biochim. Biophys.
Selinsky, Barry S.   +4 more
openaire   +2 more sources

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

open access: yesAdvanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren   +5 more
wiley   +1 more source

Ionophore-Based Electrochemical Sensors for Metal Ion Detection: Materials, Designs and Applications

open access: yesChemosensors
The accurate monitoring of metal ions is essential for applications that include environmental protection, food safety, and biomedical diagnostics. These areas depend on highly sensitive and selective methods for detecting both toxic and biologically ...
My Thi Ngoc Nguyen   +2 more
doaj   +1 more source

A New Thiourea Compound as Potential Ionophore for Metal Ion Sensor

open access: yesIndonesian Journal of Chemistry, 2018
A new thiourea compound, 2,2-oxybis(ethyl)-4-(1-naphthyl)-3-thiourea 3 has been synthesized and characterized by using FTIR, 1H-NMR, 13C-NMR, and MS spectroscopy.
Fatimatul Akma Awang Ngah   +6 more
doaj   +1 more source

Uptake of Ca2+ by isolated secretory vesicles from adrenal medulla [PDF]

open access: yes, 1982
Intact secretory vesicles isolated from bovine adrenal medulla contain 94 nmol Na+ per mg of protein, and Ca2+ influx into the vesicles is inhibited by increasing concentrations of extravesicular Na+ (but not of K+, Li+ or choline+) or by addition of the
Bashford   +19 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

open access: yesAdvanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu   +10 more
wiley   +1 more source

Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores

open access: yesPharmaceutics, 2021
The importance of zinc in biology has gained greater recognition in recent years due to its essential contributions to the function of many endogenous enzymes.
Oisín Kavanagh   +5 more
doaj   +1 more source

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