Results 11 to 20 of about 10,961 (160)

In vitro drug interaction of ionophores with artemisinin and chloroquine against Plasmodium falciparum 3D7 blood-stage infection

Frontiers in Drug Discovery, 2023
The prevalence of clinical resistance of P. falciparum towards artemisinin and its partner drugs has significantly hampered malarial chemotherapy. To circumvent this situation, identifying a new class of partner drugs with significant anti-malarial ...
Vinoth Rajendran, Keerthana Gurukkalot
doaj   +1 more source

Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry

Biomedicines, 2022
Ion channels and transporters typically consist of biomolecules that play key roles in a large variety of physiological and pathological processes.
Giacomo Picci, Silvia Marchesan, Claudia Caltagirone   +2 more
doaj   +1 more source

Potential of Ionophores as A Feed Additive for Sustainable Beef Cattle Production: Review article [PDF]

Journal of Applied Veterinary Sciences
Ionophores are naturally occurring polyether antibiotics that disrupt ion balance in bacterial cells by selectively transporting metal ions across lipid membranes, primarily affecting Gram-positive bacteria in the rumen.
Sabrina Seema, Moin Uddin, Shamsun Tamanna, Khatun-A-Jannat Esha, Kazi Md. Al-Noman, S. A. Masudul Hoque, Abu Sadeque Md. Selim, Md. Morshedur Rahman   +7 more
doaj   +1 more source

The Origin of the Non-Constancy of the Bulk Resistance of Ion-Selective Electrode Membranes within the Nernstian Response Range

Membranes, 2021
The dependence of the bulk resistance of membranes of ionophore-based ion-selective electrodes (ISEs) on the composition of mixed electrolyte solutions, within the range of the Nernstian potentiometric response, is studied by chronopotentiometric and ...
Valentina Keresten, Elena Solovyeva, Konstantin Mikhelson   +2 more
doaj   +1 more source

Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management

Molecules, 2022
Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding ...
Pratibha Pandey, Fahad Khan, Huda A. Qari, Tarun Kumar Upadhyay, Abdulhameed F. Alkhateeb, Mohammad Oves   +5 more
doaj   +1 more source

How can nutritional additives modify ruminant nutrition?

Revista de la Facultad de Ciencias Agrarias, 2022
This review illustrates the relationships between additives in the diets of ruminants and the consequence for ruminant nutrition. Feed additives are used to improve animal performance and/or the quality of the products.
Paulo Roberto Silveira Pimentel, Lara Maria dos Santos Brant, Anny Graycy Vasconcelos de Oliveira Lima, Daniela Costa Cotrim, Thiago Nascimento, Ronaldo Lopes Oliveira   +5 more
doaj   +1 more source

Efeito da Monensina e Lasalocida sobre a Atividade de Fermentação de Aminoácidos in Vitro pelos Microrganismos Ruminais Effects of Monensin and Lasalocid on Fermentation of Amino Acids in Vitro by Mixed Ruminal Bacteria

Revista Brasileira de Zootecnia, 2002
Este experimento visou estudar os efeitos in vitro dos ionóforos sobre a fermentação ruminal de aminoácidos. Utilizou-se líquido de rúmen de um novilho alimentado com dieta à base de capim-elefante, acrescentando solução de tripticase, em três ...
Rogério de Paula Lana, Juliana Silva de Oliveira, Arnaldo Chaer Borges, Rafael Gonçalves Veloso, Poliana Mary Magalhães Nunes   +4 more
doaj   +1 more source

Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?

mSphere, 2019
Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact ...
Alex Wong
doaj   +1 more source

A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis

Advanced Science, 2019
Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensively used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the ...
DaeYong Lee, Soo‐Hwan Lee, Ilkoo Noh, Eonju Oh, Hyunil Ryu, JongHoon Ha, SeongDong Jeong, Jisang Yoo, Tae‐Joon Jeon, Chae‐Ok Yun, Yeu‐Chun Kim   +10 more
doaj   +1 more source

Intoxicação por antibióticos ionóforos em animais Ionophore poisoning in animals

Pesquisa Veterinária Brasileira, 2009
O uso terapêutico de antibióticos ionóforos em medicina veterinária difundiu-se muito nos últimos anos, com conseqüente aumento no risco de intoxicação em animais.
Vivian Assunção Nogueira, Ticiana Nascimento França, Paulo Vargas Peixoto   +2 more
doaj   +1 more source