Results 41 to 50 of about 15,483 (233)

Differential Impact of Subtherapeutic Antibiotics and Ionophores on Intestinal Microbiota of Broilers

Microorganisms, 2019
Antimicrobial growth promoters (AGPs) are commonly used in the livestock industry at subtherapeutic levels to improve production efficiency, which is achieved mainly through modulation of the intestinal microbiota. However, how different classes of AGPs,
Kelsy Robinson, Sage Becker, Yingping Xiao, Wentao Lyu, Qing Yang, Huiling Zhu, Hua Yang, Jiangchao Zhao, Guolong Zhang   +8 more
doaj   +1 more source

Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin

Molecules, 2021
With drug resistance threatening our first line antimalarial treatments, novel chemotherapeutics need to be developed. Ionophores have garnered interest as novel antimalarials due to their theorized ability to target unique systems found in the ...
Daniel J. Watson, Paul R. Meyers, Kojo Sekyi Acquah, Godwin A. Dziwornu, Christopher Bevan Barnett, Lubbe Wiesner   +5 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Live performance and processing yields of broilers fed diets with tiamulin and salinomycin combinations

Brazilian Journal of Poultry Science, 2010
A study was conducted with the objective of evaluating the combined application of tiamulin (TIA) and salinomycin (SAL) in broiler diets fed from 1 to 42 d of age.
SL Vieira, A Favero, J Berres, DM Freitas, JEP Martinez, ME Mayorga, JLB Coneglian   +6 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

SARS-CoV-2 Ionophores

, 2020
Raw data for SARS-CoV-2 inhibitors, polyether ionophores. Raw data includes CellTiter-Blue assay, cytopathy nuclei count and the following for morphological profiling: Full dose-response profiles and .R script to generate plots presented in the paper ...
Svenningsen, E
core   +2 more sources

Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases [PDF]

, 2023
Transition metal dysregulation is associated with a host of pathologies, many of which are therapeutically targeted using chelators and ionophores. Chelators and ionophores are used as therapeutic metal-binding compounds which impart biological effects ...
Lee, Vanessa J, Janisse, Samuel E, Heffern, Marie C   +2 more
core   +1 more source

Chloroquine Is a Zinc Ionophore

PLoS ONE, 2014
Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis.
Jing Xue, Amanda Moyer, Bing Peng, Jinchang Wu, Bethany N Hannafon, Wei-Qun Ding   +5 more
openaire   +4 more sources

Efeito da monensina e extrato de própolis sobre a produção de amônia e degradabilidade in vitro da proteína bruta de diferentes fontes de nitrogênio Effect of monensin and propolis extract on ammonia production and in vitro degradability of crude protein of different nitrogen sources

Revista Brasileira de Zootecnia, 2004
Este experimento foi conduzido com o objetivo de avaliar a fermentação da proteína de três fontes de nitrogênio (tripticase, farelo de soja e farinha de peixe), com ou sem monensina ou extrato de própolis.
Juliana Silva Oliveira, Rogério de Paula Lana, Arnaldo Chaer Borges, Augusto César de Queiroz, Ivan Carlos C. Almeida   +4 more
doaj   +1 more source

Narasin improves ewe milk yield efficiency and may affect performance of lambs

Scientia Agricola, 2021
: Adding ionophores to ruminant diets is a strategy to manipulate ruminal fermentation and improve milk yield. This study evaluates the effects of narasin supply to lactating ewes on dry matter intake (DMI), milk yield and composition, and performance of
André Storti Martins, Daniel Montanher Polizel, Gabriela Bagio Oliveira, José Paulo Roman Barroso, Marcos Vinicius de Castro Ferraz Jr., Alexandre Arantes Miszura, Marcelo Baggio, Evandro Maia Ferreira, Alexandre Vaz Pires   +8 more
doaj   +1 more source