Results 51 to 60 of about 24,082 (237)

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Faraldo-Gómez, José D., Iglesias-Cans, Marina, Krah, Alexander, Leone, Vanessa, M. Cook, Gregory, Matthies, Doreen, Meier, Thomas, Schulz, Sarah, Yildiz, Özkan   +8 more
core   +3 more sources

Graphene‐Interfaced Stretchable Sweat Patch for Multiplexed Electrochemical Monitoring of IL‐6, Glucose, and Calcium Ions

Advanced Materials Technologies, EarlyView.
Flexible sweat sensor patch integrating graphene‑interfaced gold microelectrodes functionalized with bio‑receptors and ion‑selective membrane, coupled with a capillary‑driven microfluidic layer and portable potentiostat electronics for multiplexed monitoring of inflammatory, metabolic, and electrolyte biomarkers in microliter sweat volumes.
Roomia Memon, Ali Tufani, Süleyman Çelik, Javed H. Niazi, Anjum Qureshi   +4 more
wiley   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Liquid-Liquid Extraction Study of Sodium and Potassium Ions by a Series of Non Cyclic Ionophores Composed of Furan Units [PDF]

Journal of Sciences, Islamic Republic of Iran, 2012
A new series of noncyclic ionophores containing two to four furan units (Ia to IIIb) i.e. 1,1-difurylethane (Ia), 2,5-bis(methylfurfuryl)furan (IIa) and 1,1’ ethyledenebis[5-(methylfurfuryl)furan] (IIIa), 2,2-difurylpropane (Ib), 2,5-bis ...
L. Lokwani
doaj  

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Proton Motive Force-Dependent Hoechst 33342 Transport by the ABC Transporter LmrA of Lactococcus lactis [PDF]

, 2005
The fluorescent compound Hoechst 33342 is a substrate for many multidrug resistance (MDR) transporters and is widely used to characterize their transport activity.
Abbreviations ABC, Chen M., Doerrler W. T., Ecker G. F., Gajic O., Haugland R. P., Higuchi R., Ketchum C. J., Kuipers O. P., Lalande M. E., Lanzetta P. A., Lewinson O., Linnett P. E., Lubelski J., Lubelski J., Margolles A., Mazurkiewicz P., Orelle C., Paternostre M. T., Poelarends G. J., Putman M., Sakamoto K., Sambrook J., Shapiro A. B., Shapiro A. B., Shapiro A. B., Shapiro A. B., Sharma S., Steinfels E., Urbatsch I. L., van Veen H. W., van Veen H. W., van Veen H. W., Venter H., Viitanen P., Yu J. L.   +35 more
core   +2 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides

Molecules, 2014
A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods.
Michał Antoszczak, Ewa Maj, Agnieszka Napiórkowska, Joanna Stefańska, Ewa Augustynowicz-Kopeć, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski, Adam Huczyński   +8 more
doaj   +1 more source

Epoxide-Opening Cascades in the Synthesis of Polycyclic Polyether Natural Products [PDF]

, 2009
The structural features of polycyclic polyether natural products can, in some cases, be traced to their biosynthetic origin. However in case that are less well understood, only biosynthetic pathways that feature dramatic, yet speculative, epoxide-opening
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core   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source