Results 51 to 60 of about 15,483 (233)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Screening of organoboron compounds as potential ionophores in a miniaturized ITIES cell. [PDF]

Screening ionophores for potentiometric ion-selective electrodes is arduous as the interaction between the ion and the recognition molecule might be obscured by improper selection of the plasticizer, lipophilic salt or its concentration.
Martyna, Durka, Emilia, Witkowska Nery, Sergiusz, Luliński, Krzysztof, Durka   +3 more
core   +2 more sources

A Scientific Journey with Ionophore-based Sensors

CHIMIA, 2020
This article describes selected historical milestones in the field of neutral ionophore-based sensors, starting with the first discovery by Wilhelm Simon and their impact to analytical sciences despite the initial difficulty to understand their function.
Eric Bakker
doaj   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Ionophores

, 2006
This revised and expanded reference is a valuable aid for the practicing veterinary clinician in diagnosing and determining treatment for toxic exposures in small animals, and for veterinary students as a supplement to their classroom instruction. It contains chapters addressing nontraditional areas of toxicology not covered in conventional toxicology ...
openaire   +2 more sources

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Carcass quality of feedlot finished steers fed yeast, monensin, and the association of both additives Qualidade de carcaça de novilhos terminados com dietas contendo levedura, monensina e associação de ambos aditivos

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2009
To evaluate the effects of the supplementation of feed additives on carcass quality in beef cattle, 72 Nellore steers (339.5kg, 20-month old) were feedlot finished and fed for 91 days one of the following diets: 1) control with no additives; or added of ...
R.C. Gomes, P.R. Leme, S.L. Silva, M.T. Antunes, C.F. Guedes   +4 more
doaj   +1 more source

Special issue in honour of Prof. Reto J. Strasser - Probing the photosynthetic apparatus noninvasively in the laboratory of Reto Strasser in the countryside of Geneva between 2001 and 2009

Photosynthetica, 2020
An overview is given of several studies on the fast chlorophyll (Chl) a fluorescence (OJIP) transient carried out in the laboratory of Reto Strasser between 2001 and 2009.
S.Z. TÓTH, A. OUKARROUM, G. SCHANSKER   +2 more
doaj   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, EarlyView.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides

Molecules, 2014
A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods.
Michał Antoszczak, Ewa Maj, Agnieszka Napiórkowska, Joanna Stefańska, Ewa Augustynowicz-Kopeć, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski, Adam Huczyński   +8 more
doaj   +1 more source