Results 51 to 60 of about 10,885 (191)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Effect of ionophores on ruminal fermentation [PDF]

Applied and Environmental Microbiology, 1989
Article synthese concernant les effets des ionophores, en particulier la monensine, sur l'ecologie, sur le metabolisme microbien, et la physiologie membranaire de la flore microbienne des ...
J B, Russell, H J, Strobel
openaire   +2 more sources

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Outbreak of monensin poisoning in equines: clinical signs, histopathologic findings and chromatographic diagnosis [PDF]

Ciência Rural
: Ionophores are polyether antibiotics used in animal production for ruminants and birds to promote growth and exert coccidiostat action. Despite the benefits of their use, poisonings have also been reported in several species. Equines are very sensitive,
Nelcimara Mirley de Souza Correia, Wagner Luís Fernandes, Mary Ane Gonçalves Lana, Isadora David Tavares de Moraes, Julia Paiva Nunes, Jéssyca Ataíde Ferreira, Monica Chacon de Vicente, Alexandre Có Mangoni Barros, Ana Rita Rodrigues Guimarães, Murilo Rodrigues de Souza, Ana Luísa Soares de Miranda, Marina Pacheco Miguel, Paulo José Bastos Queiroz, Danieli Brolo Martins, Leandro Guimarães Franco, Luciana Ramos Gaston Brandstetter, Ana Flávia Machado Botelho   +16 more
doaj   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

Evolutionary trade‐offs between beauvericin production and growth define divergent virulence strategies in Beauveria

Pest Management Science, EarlyView.
Two virulence strategies in Beauveria: a growth strategy characterized by rapid within‐host proliferation, and a toxin strategy involving antimicrobial activity and toxicity to insects Abstract BACKGROUND Pathogen virulence is often attributed to toxin production, yet toxins are metabolically costly and may not universally enhance fitness.
Shasha Hu, Lana L B de Carvalho, Ricardo A Polanczyk, Michael J Bidochka   +3 more
wiley   +1 more source

Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death

Advanced Science
Despite the initial efficacy of enzalutamide in castration‐resistant prostate cancer (CRPC), inevitable resistance remains a significant challenge. Here, the synergistic induction of copper‐dependent cell death (cuproptosis) in CRPC cells is reported by ...
Xiang Gao, Haolin Zhao, Jiao Liu, Min Wang, Zhihong Dai, Wenjun Hao, Yanlong Wang, Xiang Wang, Min Zhang, Pixu Liu, Hailing Cheng, Zhiyu Liu   +11 more
doaj   +1 more source

SAFE: a Mix‐and‐Read Assay for miRNA Detection in Extracellular Vesicles From Unprocessed Plasma Toward Clinical Disease Diagnosis

Small, EarlyView.
SAFE (Sonication‐Assisted liposome Fusion with EVs) is a rapid, mix‐and‐read assay that directly detects extracellular vesicle–encapsulated miRNAs from unprocessed plasma. By delivering molecular beacons into EVs via sonication‐driven liposome fusion, the method enables intravesicular hybridization with minimal background, providing quantitative ...
Subhra Sulipta Jena, Soo Jin Kim, Hyeonha Jang, Lianhua Chi, Yunji Eom, Kyung‐Oh Doh, JaeJong Lee, Jun Seok Park, Junyeop Lee, Seonki Hong   +9 more
wiley   +1 more source