Results 61 to 70 of about 10,885 (191)

Immunocastration on performance and meat quality of Bos indicus (Nellore) cattle under different nutritional systems

Scientia Agricola, 2020
: The present study aimed to evaluate the effects of immunocastration on the animal growth, carcass traits, and meat quality of Nellore cattle receiving or not Ionophore supplementation at pasture or pasture with concentrate (semi-feedlot).
Rickyn Alexander Jacinto-Valderrama, Guilherme Sicca Lopes Sampaio, Maria Lucia Pereira Lima, Joslaine Noely dos Santos Gonçalves Cyrillo, Sergio Bertelli Pflanzer   +4 more
doaj   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Protozoários ciliados do rúmen de bovinos e bubalinos alimentados com dietas suplementadas com monensina ou própolis Ruminal ciliate protozoa of cattle and buffalo fed on diet supplemented with monensin or extracts from propolis

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi avaliar o efeito de dietas suplementadas com monensina ou produtos à base de própolis, nas populações de protozoários ciliados no rúmen de bovinos (Bos taurus) e bubalinos (Bubalus bubalis).
Thaís Barros Ríspoli, Isabella Lopes Rodrigues, Rafael Gioia Martins Neto, Ricardo Kazama, Odimari Pricila Pires Prado, Lúcia Maria Zeoula, Pedro Braga Arcuri   +6 more
doaj   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, EarlyView.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Monensina para bezerros ruminantes em crescimento acelerado: 2. Digestibilidade e parâmetros ruminais Monensin for ruminant calves in fast rate growth: 2. Digestibility and ruminal parameters

Revista Brasileira de Zootecnia, 2000
Os efeitos da suplementação de monensina nos parâmetros ruminais e na digestibilidade foram analisados após 120 dias de experimentação, utilizando-se 20 bezerros inteiros holandeses com peso e idade médios de 90,8 kg e 80 dias, respectivamente.
Márcia Saladini Vieira Salles, Carlos de Sousa Lucci   +1 more
doaj   +1 more source

Mast Cells Selectively Deliver Extracellular Vesicle‐Encapsulated mRNA to Colorectal Cancer Cells

Immunology &Cell Biology, EarlyView.
Schematic overview of mast cell‐colorectal cancer cell interactions. Mast cells bind to colorectal cancer cells through integrin‐mediated adhesion (1). Calcium influx arises in mast cells (2). Calcium signaling is required for the release of mRNA‐ and protein‐containing vesicles (3), resulting in the transfer of mast cell‐derived mRNA and proteins to ...
Rosie Lanzloth, Bader El Farran, Ram Podicheti, Douglas B. Rusch, Heather M. O'Hagan   +4 more
wiley   +1 more source

Avaliação da monensina administrada pela forma convencional ou por dispositivo de liberação lenta (bólus) em bovinos alimentados com forragens de baixo valor nutritivo e suplementados ou não com uréia Evaluation of the monensin fed as a conventional form or as a controlled release capsule (bolus) in bovine fed forage of low nutritive value and supplemented or not with urea

Revista Brasileira de Zootecnia, 2007
Foi objetivo desta pesquisa avaliar os efeitos da monensina sódica administrada pela forma convencional ou por dispositivo de liberação lenta sobre o perfil fermentativo ruminal de bovinos alimentados com volumosos de baixo valor nutritivo e ...
Paulo Henrique Mazza Rodrigues, Kleber da Cunha Peixoto Júnior, Sérgio Carlo Franco Morgullis, Estela Jorge Alves da Silva, Paula Marques Meyer, Alexandre Vaz Pires   +5 more
doaj   +1 more source